Objective
The first cell divisions of an embryo occur in the absence of transcription. Therefore, early embryonic development is dependent on maternally stored proteins and mRNA. Recent findings have shown that maternally deposited proteins are long-lived, suggesting that they play critical roles beyond fertilization. Interestingly some of these long-lived proteins play a role in metabolism. Maternal nutrient stores such as lipids and glycogen are available in the oocyte, however to what degree and when they contribute to the metabolism and epigenetic state of the embryo is poorly defined. In metabolic disorders linked to infertility such as obesity, diabetes and polycystic ovarian syndrome (PCOS) these maternal stores are changed. This project aims to investigate how maternal glycogen and lipid stores regulate the metabolic reprogramming of preimplantation embryos and characterize the metabolic awakening of the embryo. First, I will use 13C isotope-labeled nutrients and MALDI-MSI to trace when maternal stores are utilized in preimplantation mouse embryos. Second, I will perturb glycogen and lipid stores using dietary, mRNA or protein depletion (siRNA/TRIM-Away), and pharmacological tools to determine their functional role in development. Overall, this study will provide the first spatio-temporal map of maternal nutrient utilization in early embryos and functionally define the role of metabolic stores. The insights gained will improve our understanding of metabolic regulation during early development and may inform future strategies for enhancing IVF outcomes and reproductive health.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine gynaecology reproductive medicine
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences clinical medicine embryology
- medical and health sciences health sciences nutrition obesity
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1165 KOBENHAVN
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.