Objective
In this project, I will investigate the inflammatory and placental mechanisms underlying the high risk of pre-eclampsia in sickle cell disease (SCD), the most common inherited hemoglobinopathy worldwide and a major global health problem. I will employ immunological, vascular, and transcriptomic approaches to characterize how chronic inflammation, oxidative stress, and angiogenic imbalance contribute to pre-eclampsia in SCD pregnancies. Using plasma, PBMCs, and placental samples, I will define immune and vascular signatures, map placental transcriptional programs through single-cell and single-nucleus RNA sequencing, and assess the impact of transfusion and hydroxyurea on trophoblast inflammatory and vascular responses. I will integrate these datasets to identify mechanistic pathways and prioritize candidate biomarkers for clinical translation. My project will provide the first systems-level map of maternal–placental inflammation in SCD pregnancy, generating insights that can guide risk stratification and therapeutic strategies to improve maternal and fetal outcomes. My background in SCD pathophysiology, thrombosis, and oxidative stress is highly complementary to the expertise of my supervisors, Dr. Thiago Maciel, an expert in inflammation and erythropoiesis, and Dr. Sara El Hoss (co-supervisor), an expert in ineffective erythropoiesis, SCD pathophysiology and pregnancy. I will further benefit from a secondment at King’s College London with Dr. Panicos Shangaris, an expert in maternal–fetal medicine, which will provide advanced training in placental functional assays. This fellowship will allow me to expand my research scope into pregnancy complications in SCD, bridging mechanistic biology and clinical translation, and positioning me to develop into an independent investigator.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine angiology vascular diseases
- medical and health sciences basic medicine physiology pathophysiology
- medical and health sciences clinical medicine obstetrics fetal medicine
- natural sciences biological sciences genetics RNA transcriptomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75015 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.