Objective
Messenger RNA (mRNA) therapeutics have shown great promise for treating infections, cancer, and genetic diseases, but their production is expensive, complex, and difficult to scale. Current methods rely on cell-free systems that use costly enzymes and building blocks, limiting access to these therapies. There is a growing need for new ways to make mRNA that are affordable, reliable, and suitable for producing many different types of mRNA, including advanced formats such as self-amplifying RNA (saRNA), which can produce more therapeutic effect with lower doses. The ARISE project aims to create a new, yeast-based platform for large-scale, low-cost mRNA manufacturing. Yeasts are simple organisms that naturally make mature mRNA similar to that found in human cells, and they can be grown quickly and cheaply in industrial systems. However, mRNA inside yeast is normally broken down very quickly, preventing its use for medicine production. ARISE will overcome this by developing a method that switches on production of the desired mRNA inside yeast only when needed and stores it in special safe compartments, protecting it until it can be collected. The stored mRNA will then be extracted and purified using a simple and scalable process, enabling production of both standard and long mRNAs. ARISE project will also adapt the system to make complex, long self-amplifying RNAs, which contain the instructions for both the therapeutic protein and the machinery to copy themselves in the host’s cells. Finally, ARISE will scale up the process to pilot level, preparing it for industrial use. By lowering costs and enabling true large-scale production, ARISE will remove a major barrier to the development and fair distribution of mRNA medicines worldwide, supporting public health preparedness and innovation in advanced therapies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.3.1 - The European Innovation Council (EIC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-EIC - HORIZON EIC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-EIC-2025-TRANSITIONOPEN
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
33600 PESSAC
France
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.