Objective
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating multisystem disease affecting up to 1% of the population. It is defined by post-exertional malaise, persistent fatigue, cognitive and neurological symptoms, and autonomic, endocrine, and immune dysfunction. Clinical heterogeneity and the absence of specific diagnostic tests lead to long delays in diagnosis, lack of effective therapies, and a socioeconomic burden exceeding €40 billion annually in Europe.
DISCOVER-ME will deliver the first clinically actionable, biologically validated stratification framework for ME/CFS. Through harmonised clinical phenotyping of 2,000 patients and multi-omics profiling of >900 samples from five European biobanks, the project will identify, validate, and prioritise biomarkers across (epi)genetic, immune, metabolic, neuroendocrine, and vascular domains. This large-scale, reproducible approach overcomes decades of fragmented, underpowered studies that have stalled progress.
Three innovations set DISCOVER-ME apart: (i) a robust biomarker discovery and validation pipeline; (ii) the first systems-level taxonomy of ME/CFS grounded in mechanistic disease drivers and supported by AI-assisted stratification; and (iii) open-access disease maps and digital twin models that combine biological mechanisms with social and economic determinants of health, enabling in silico testing of therapeutic hypotheses. These outputs will underpin biomarker-guided clinical trials and precision drug repurposing.
Patient involvement is embedded throughout—from co-design of phenotyping tools to surveys, stratification frameworks, and policy recommendations—ensuring that lived experience informs all biomedical and computational outputs. By integrating patient, clinical, and biological perspectives, DISCOVER-ME will deliver evidence and tools directly relevant to patients, clinicians, and health systems.
Fields of science (EuroSciVoc)
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.2.1 - Health
MAIN PROGRAMME
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HORIZON.2.1.3 - Non-Communicable and Rare Diseases
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-RIA - HORIZON Research and Innovation Actions
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-HLTH-2025-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1090 Wien
Austria
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Participants (20)
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NR4 7UQ NORWICH
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46001 Valencia
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CF10 3AT CARDIFF
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N6A 3K7 ONTARIO - LONDON
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751 05 Uppsala
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H91 Galway
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75794 Paris
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
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31400 Toulouse
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1081 HV Amsterdam
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8000 Aarhus C
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8020 Graz
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116 38 STOCKHOLM
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11000 Belgrade
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SW7 2AZ London
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1080 WIEN
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
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46010 Valencia
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2200 COPENHAGEN
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WC1E 7HT London
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101 Reykjavik
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700 13 IRAKLEIO
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