Objective
Regulatory T cells (Tregs) are vital for maintaining homeostasis and self-tolerance. This immunosuppressive nature is exploited by cancer for tumour growth. Consequently, Treg accumulation in tumors is associated with poor prognosis and is a fundamental impediment to the success of immunotherapy. Thus, Treg suppressive mechanisms emerge as appealing therapeutic targets. However, current approaches focus on their systemic elimination, failing to yield significant clinical outcomes and are accompanied by harmful autoimmune toxicities. The ERC-funded project RegSign discovered a novel, unexpected metabolic mechanism whose therapeutic targeting has the unique advantage of restraining the immunosuppressive action of Tregs specifically in the tumor, without eliminating them, while protecting their beneficial effect on the periphery. Based on these findings, this PoC project, MetaReg will develop and validate Treg-targeted nanoplatforms tailoring Treg metabolism to disrupt their immunosuppressive function specifically in tumors while preserving their fitness in the periphery. To navigate the pathway from research to innovation, MetaReg will optimize the nanosystems, demonstrate their safety and efficacy in humanized mouse models, secure IP, and assess licensing strategies. MetaReg envisions bridging the “valley of death” between fundamental discoveries and clinical translation, opening new avenues in cancer immunotherapy.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology cell metabolism
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine immunology immunotherapy
- medical and health sciences basic medicine physiology homeostasis
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2025-POC
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
115 27 ATHINA
Greece
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.