Objective
The project “Community-Based Scale up of integrated community health worker-led cardiovascular risk factor (CVRF) management” (ComBaScale) aims to empower community health workers (CHWs) in under-resourced settings to deliver a high-quality, evidence-based, holistic package of integrated care for CVRF. Its scalability will be tested in two districts of Lesotho, a low-income country disproportionately affected by a rising burden of non-communicable diseases (NCDs). Guided by a validated implementation framework, trial evidence on the safety and effectiveness of CHW-led titration of antihypertensive and antidiabetic therapy will be translated into practice, while embedded in the national system. A pilot study will refine the intervention and align it with CHWs’ routine responsibilities, including HIV and tuberculosis screening, before roll-out through a stepped-wedge cluster randomised trial with a hybrid effectiveness–implementation design. The CHWs will be supported by a patient-facing clinical decision-support application, interoperable with the national information system and featuring an innovative authoring tool to ensure safety and guideline fidelity. The trial will include an equity-informative extended cost-effectiveness analysis, while mixed-methods will examine acceptability, stigma, and gender-related barriers. People living with CVRF will play a central role in co-developing and monitoring the intervention via community advisory boards, alongside village authorities, implementing partners, and researchers. All trial results, implementation frameworks, training material, and digital tools will be compiled in a comprehensive toolkit and piloted in a separate district for further scale-up. By applying the principles of implementation science throughout, ComBaScale will generate a validated, co-created, integrated CVRF care package, ready for adaptation across Lesotho and other under-resourced populations to reduce the NCD burden globally.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences infectious diseases RNA viruses HIV
- medical and health sciences clinical medicine pneumology tuberculosis
- medical and health sciences clinical medicine cardiology cardiovascular diseases
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.2.1 - Health
MAIN PROGRAMME
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HORIZON.2.1.6 - Health Care Systems
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HORIZON.2.1.3 - Non-Communicable and Rare Diseases
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-RIA - HORIZON Research and Innovation Actions
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-HLTH-2025-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
2000 ANTWERPEN
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.