Objective
Head and neck cancer (HNC) kills half a million people every year, with 1.5 million new cases diagnosed worldwide. Following initial treatment recurrence rate is high ~40–70% and current treatment options for recurrent HNC (rHNC) show poor efficacy and severe side effects , with a median survival of only 10 months.
We have developed the first biologically targeted radiotherapy, called BNCT/TB0010, which uses tumour-targeting antibodies to deliver boron (10B) specifically to EGFR positive tumour cells for effective local control while sparing normal tissues. .
TB0010, a second-generation boron 10B carrier shows revolutionary properties to overcome current issues with first-generation 10B carriers especially targeted accumulation in cancer cells with minimal side effects and low invasiveness, representing a potentially lifesaving option for patients with high unmet need in rHNC.
BIOTARGET0010 aims to advance the clinical development of biological tumour-targeting radiotherapy with a multicentre Phase 1b/2 trial in EGFR positive rHNC patients, demonstrating safety and preliminary efficacy of TB0010/BNCT as a basis for pivotal trials.
Our cohesive interdisciplinary team with relevant experience and expertise, and appropriate infrastructure ensures the successful delivery of BIOTARGET0010. Our consortium covers expertise in nuclear physics, chemistry and biology, together with , clinical oncology and regulatory affairs, drug manufacturing, HNC, communication and patients’ engagement.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology head and neck cancer
- natural sciences chemical sciences inorganic chemistry metalloids
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.2.1 - Health
MAIN PROGRAMME
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HORIZON.2.1.5 - Tools, Technologies and Digital Solutions for Health and Care, including personalised medicine
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-RIA - HORIZON Research and Innovation Actions
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-HLTH-2025-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
18071 Granada
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.