Objective
MyoSTAR will develop the first scalable, allogeneic, off-the-shelf muscle stem cell therapy, placing Europe at the forefront of regenerative medicine. Muscle-wasting diseases and injuries affect over 20 million Europeans in emergency care, orthopedics, neurology, trauma, and iatrogenic settings, causing disability, loss of independence, premature death, and rising healthcare costs. Current treatments are mainly symptomatic and do not restore muscle function. Skeletal muscle regenerates via satellite cells and autologous muscle stem cell therapies have shown promise, especially in pediatric and orphan diseases. Much of this innovation has been pioneered in Europe, with the consortium partner MyoPax among the leaders. Yet, broad use is limited by complex manufacturing, distribution limits, immune rejection, inconsistent quality and safety, and the lack of standardized delivery. MyoSTAR will overcome these barriers by creating immune-cloaked, safety-equipped induced satellite cells (iSats) from hiPSCs - a universal, robust, readily available regenerative source. AI-powered quality control will ensure genomic integrity; closed-system GMP workflows will streamline manufacturing, and new potency assays will link in vitro function to in vivo regeneration. To ensure clinical adoption, a robotic injection system will deliver iSats with precision and consistency. Seven leading partners from industry, biotech, and academia unite expertise to establish a fully preclinically validated, GMP- and regulator-ready iSat product, advancing to first-in-human trials in post-prostatectomy incontinence, a disabling condition with no regenerative option. Beyond this, the platform will expand to broader muscular diseases. By advancing stem cell engineering, AI-driven manufacturing, and precision delivery, MyoSTAR will create the first clinically ready, scalable platform for muscle regeneration offering realistic curative options and positioning Europe´s leadership in stem cell innovation.
Fields of science (EuroSciVoc)
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.2.1 - Health
MAIN PROGRAMME
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HORIZON.2.1.5 - Tools, Technologies and Digital Solutions for Health and Care, including personalised medicine
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-RIA - HORIZON Research and Innovation Actions
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-HLTH-2025-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
13353 Berlin
Germany
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.