Objective
This action is part of the Cancer Mission cluster of projects on “Diagnosis and Treatment-Innovative Surgery”.
BACKGROUND: Pancreatic cancer is the deadliest solid tumour in Europe, with a 5-year survival of 13%. Locally advanced pancreatic cancer (LAPC) affects >50,000 Europeans annually and is essentially fatal without surgery. In recent years, expert centres have doubled their LAPC-resection rates up to 20% through novel multimodal systemic therapy and surgical techniques. However, randomised trials confirming the benefit of this approach are lacking. In most European countries max 5% of patients with LAPC undergo resection. This inequity translates into survival gaps of 20% between countries, making LAPC one of the clearest examples of cancer inequality in Europe.
AIM: PALACROS will optimise surgery-centred multimodal LAPC-treatment across Europe through training and (randomised) trials.
APPROACH: PALACROS will roll out a pan-European training programme in six mentee countries, doubling surgical resection rates. For durable improvement also in non-expert centres, patient selection will be optimised by developing harmonised eligibility criteria supported by AI-based identification of candidates for LAPC-resection via imaging. Outcome collection is optimised through a Core Outcome Set co-designed with patients including survival, quality of life, and cost-effectiveness.We will perform the first international RCT comparing surgery with MRI-guided stereotactic body radiotherapy after induction chemotherapy to deliver strong evidence of benefit of the multimodal surgical approach in LAPC. This is complemented by two trials on innovative intratumoural therapies. A GDPR/EHDS-compliant federated data and biobank platform will secure sustainability.
IMPACT: PALACROS will double LAPC resection rates from <5% to 10% in at least 6 European countries, extending median survival by 6 months and improving quality of life for thousands of patients. It will provide level-1 evidence to update guidelines, reimbursement, and cancer plans, while embedding training, equity, and patient voices.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine surgery
- medical and health sciences clinical medicine oncology pancreatic cancer
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.2.1 - Health
MAIN PROGRAMME
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HORIZON.2.1.6 - Health Care Systems
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HORIZON.2.1.3 - Non-Communicable and Rare Diseases
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-RIA - HORIZON Research and Innovation Actions
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MISS-2025-02
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1081 HV Amsterdam
Netherlands
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Participants (21)
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37129 Verona
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69117 Heidelberg
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
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69120 Heidelberg
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182 33 DANDERYD
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1000 Bruxelles / Brussel
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0450 Oslo
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10707 Berlin
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
6227 BG Maastricht
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The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
104 22 Stockholm
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56126 Pisa
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35122 Padova
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6525 GA Nijmegen
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1080 VIENNA
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8010 Graz
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3400 Hillerod
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40 055 Katowice
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01513 Vilnius
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4020 Linz
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B15 2PR Birmingham
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022328 Bucuresti
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1090 Wien
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