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Multimodal data Integration and AI-based REsearch on environmental exposures in children and Young Adult cancers

Objective

MIREYA is a pan-European, multi-omic, multi-exposures and multi-disciplinary project that advances research and delivers a yet unavailable understanding of the impact and causal pathway of multiple environmental exposures on the development and outcomes in rare children (0-14 years) and adolescent and young adults (15-39 years [AYA]) cancers (i.e. embryonal tumours, central nervous system and colorectal cancers). The project will leverage an unparalleled amount of epidemiology datasets from population-based cancer registries from 9 European Countries - collecting data for about 65,000 children and AYA with rare and less studied cancers and more than 500,000 controls – with large pan-European datasets on environmental exposures and socioeconomic position information. These datasets will be integrated with omic data, producing and making available a multisource pan European dataset aligned with the UNCAN and the EHDS platforms. This wealth of data will allow us to identify personalised biological fingerprints of the exposures and define their impact at biological level. Using multilayered research approaches based on reuse, integration and innovative AI-causal-driven analysis of multi-source and multi-disciplinary data (e.g. biological, environmental, social and economic) we will disentangle the combined role of host features and environmental exposures on development and outcomes of cancer in children and AYAs at different stages of life. We will further add to these advances by building the first base of evidence on the potential economic impact of prevention policies aimed at modifiable risks also through social protection measures on cancer inequalities among children and AYAs. This action is part of the Cancer Mission cluster of projects on ‘Understanding (environmental exposure in Children and Adolescent and young adults - CAYAs)

Fields of science (EuroSciVoc)

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Keywords

Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)

Programme(s)

Multi-annual funding programmes that define the EU’s priorities for research and innovation.

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

HORIZON-RIA - HORIZON Research and Innovation Actions

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) HORIZON-MISS-2025-02

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Coordinator

FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 525 000,00
Address
Via Venezian 1
20133 Milan
Italy

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Region
Nord-Ovest Lombardia Milano
Activity type
Research Organisations
Links
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 525 000,00

Participants (20)

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