Objective
Improved therapy of peritoneal metastases (PM) and malignant pleural effusion (MPE) is an important clinical need. Recently, intracavitary aerosolized drug delivery (ADD) has been introduced in the treatment of PM and MPE. This innovative, EU developed therapy involves nebulization of chemotherapy during either laparoscopy (pressurized intraperitoneal aerosolized chemotherapy, PIPAC) or thoracoscopy (pressurized intraperitoneal aerosolized chemotherapy, PIPAC). Also, preliminary data suggest that ADD may be optimized by using electrostatic precipitation (ESP). As yet, however, no randomized trials have tested the efficacy of PIPAC or PITAC. The IMPACT project aims to establish ADD as a novel standard of care in patients with PM and MPE. First, a comprehensive assessment of patient needs and expectations will be performed, supported by experts in participatory research methods. Based on the input of multiple stakeholders including patients, methodologists, and health care professionals, three randomized clinical trials will be designed in PM from colorectal and gastric cancer, and in MPE. These trials will be run in more than 30 clinical sites in 7 EU countries, and will include >500 patients. In a subgroup of patients, the effects of ESP on drug distribution and tumor tissue penetration will be studied. In addition to clinical and patient related outcomes, health technological assessment will be performed to establish cost effectiveness and value in diverse EU health care systems. To reach all relevant stakeholders, a broad range of communication, exploitation, and dissemination tasks will be performed in order to maximize the visibility and impact of the project results. In parallel, a modular implementation strategy will be deployed to maximize clinical adoption of this innovative treatment strategy and ensure acceptability, usability, and scalability in diverse health care settings.
This action is part of the Cancer Mission cluster of projects on “Diagnosis and Treatment-Innovative Surgery
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.2.1 - Health
MAIN PROGRAMME
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HORIZON.2.1.6 - Health Care Systems
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HORIZON.2.1.3 - Non-Communicable and Rare Diseases
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-RIA - HORIZON Research and Innovation Actions
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MISS-2025-02
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
9000 Gent
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.