Objective
At present, across EU countries, 30-50 per 1 million children develop acute lymphoblastic leukaemia (ALL) every year, making it the most frequent cancer in children. The overarching objective of ELI-ALL (Towards the elimination of ALL in children) project is to ultimately establish the potential relationship between environmental exposures and the risk of developing ALL during childhood, utilizing established and enhancing scientific insights into molecular mechanisms. The ambition is to, from this newly established scientific evidence base, develop and implement primary prevention so that fewer children in Europe and around the globe develop the commonest cancer in children.
ELI-ALL will investigate the link between maternal exposure during pregnancy or early childhood exposure to air pollution, per-and polyfluoroalkyl substances (PFAS) and pesticide and risk of preleukaemic clones and ALL.
ELI-ALL combines i) the world’s largest and longest-running cohorts of newborns with already collected maternal biological samples (blood and urine) to directly investigate the link between various environmental chemicals and the presence of preleukaemic clones in newborns ii) prospective cohort or nested registry-based studies with modelled environmental exposure data of several physical agents, including large numbers of registered ALL patients; iii) epigenetic trajectory studies based on the same cohorts of newborns to identify the epigenetic drivers, their potential reversibility and their relation to environmental exposures across the trajectory of ALL from birth to diagnosis and prognosis; iv) comparative empirical bioethics approach situated at the interface of bioethics, sociology, and law/social policy to investigate the practical-ethical questions related to environmental, genetic and epigenetic, omics and other factors influencing the onset and development of cancers in children, and define standards of good ethical practice and communication; v) a scientific consensus-based evaluation on the carcinogenicity of selected PFAS compound through a Monograph evaluation.
This action is part of the Cancer Mission cluster of projects on ‘Understanding(environmental exposure in CAYA).
Fields of science (EuroSciVoc)
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.2.1 - Health
MAIN PROGRAMME
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HORIZON.2.1.2 - Environmental and Social Health Determinants
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HORIZON.2.1.3 - Non-Communicable and Rare Diseases
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-RIA - HORIZON Research and Innovation Actions
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MISS-2025-02
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
69007 Lyon 7eme
France
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Participants (15)
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3012 Bern
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55131 Mainz
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0456 Oslo
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75654 Paris
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
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93322 AUBERVILLIERS CEDEX
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1165 KOBENHAVN
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40225 Dusseldorf
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86159 Augsburg
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33100 Tampere
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751 05 Uppsala
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53-111 Wroclaw
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10408 Goyang
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120 750 Seoul
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
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03760 SEOUL
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3584 CS Utrecht
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Partners (2)
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3052 Parkville
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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305 8506 Tsukuba
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