Objective
Spatial biology is bottlenecked by 2D-based platforms that cannot profile intact 3D tissues, such as organoids, at scale. This gap is acute in drug discovery, where organoids and other 3D culture models in 96/384-well format are increasingly adopted, accelerated by EU and FDA roadmaps to reduce animal use. Spatial Fuseseq directly addresses this unmet need with an entirely new way to spatially barcode molecules inside intact 3-dimensional tissue samples for downstream DNA sequencing and computational volumetric (3D) reconstruction at high resolution and low cost.
Building on results of an ERC PoC and subsequent improvements that together established feasibility on cells and tissue sections (TRL4), this EIC Transition project will advance Spatial Fuseseq to TRL6 and a first market-ready configuration for organoid-based drug development. Technologically, we will (i) develop and automate sample-preparation for organoids (96/384-well), (ii) expand to whole-transcriptome profiling, (iii) deliver validated computational pipelines for 3D reconstruction and visualization, and (iv) produce prototype reagent kits with QC assays and a beta software version for user testing. Commercially, we will (v) validate problem–solution fit via voice-of-customer interviews, and (vi) run early-access pilots—first in-house, then at user sites—to demonstrate the technology in relevant environment (TRL6) and its readiness for scale.
The global spatial biology market is dominated by US players, while Europe leads in novel 3D culture models for translational drug discovery. Anchoring Spatial Fuseseq in Europe ensures that the enabling spatial platform for 3D culture model analysis is not imported but developed, owned, and commercialized within the EU, securing high-value IP, skilled jobs, and economic growth, strengthening EU sovereignty and positions European SMEs and Pharma to lead globally.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- natural sciences computer and information sciences software
- natural sciences biological sciences genetics DNA
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.3.1 - The European Innovation Council (EIC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-EIC - HORIZON EIC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-EIC-2025-TRANSITIONOPEN
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
171 65 Solna
Sweden
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.