Objective
Cancer research efforts nowadays are focused on improving patients’ quality of life through targeted therapies, that decrease adverse effects while improving survival. GRAPE will contribute to this aim by developing therapeutic agents based on biocompatible gold-based nanoparticles (NPs), which will predictably improve proton beam therapy (PBT) outcomes. This will be achieved by not only enhancing the effect of PBT, but also minimizing the off-targeted toxicity that induces damaging of healthy tissues located at the tumor periphery, leading to lower adverse effects related to radiotherapy lack of specificity.
The use of therapeutic nanoplatforms could also be used as a starting point for personalized medicine. The physico-chemical properties of the NPs can be rationally designed according to different needs. Additionally, NPs will be functionalized with active targeting in order to enable selective delivery and accumulation inside glioblastoma multiforme (GBM) cancer cells overexpressing certain markers. After testing NPs selective uptake and toxicity in GBM cells, they will be administered in vivo to assess NP retention by tumor tissue. Then, their therapeutic potential will be assessed in vitro employing a clinical proton therapy equipment. Finally, we will preliminary test their therapeutic effect in vivo, employing oncologic mice models with the same clinical equipment.
Not only GRAPE aims to provide a more personalized therapy for GBM patients, but also for other cancer types. Once the NPs are validated in GBM, their versatility and adaptability will allow the anchoring of other targeting ligands for surface markers specifically overexpressed by other cancer cells, thus expanding overall oncology treatment options.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2025-POC
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
28006 MADRID
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.