Objective
Preclinical mouse tumor models are an indispensable experimental tool in cancer research. In turn, they also have limitations since most mouse tumor models do not adequately mimic the course of tumor development as it occurs in humans or the response to therapy. Moreover, there is no standardization of tumor models making it oftentimes difficult to compare the results of different studies. Lastly, animal welfare aspects casts increasing societal doubts about animal experimentation. We have within the ERC AdG grant “Angiomature” pioneered new mouse tumor models that overcome the limitations of currently employed models and have the potential to fundamentally change the way preclinical mouse tumor work is done. Instead of grafting cultured tumor cell lines into recipient mice, we transplant small fragments of established tumors obtained from genetically engineered mouse models. These fragments can be biobanked and thereby conveniently shipped throughout the world enabling a hitherto unprecedented level of tumor model standardization. Within the SpheroMouse PoC project, we propose to pursue experimental work to advance this novel preclinical mouse tumor model approach from academic lab established standard into a versatile commercialisable platform of miniaturized, biobanked, injectable, shippable, and fully multiomics standardized fragment-based tumor models. We will also expand the scope of the model platform from presently two to 10 different models, covering most of the major solid tumor entities. Collectively, the SpheroMouse PoC project serves a threefold purpose, namely first, to develop the implementation potential of the platform in preparation for a spinoff that will market the novel standardized tumor models, second, to make a strong contribution to the 3R principles of animal welfare, and third, to substantially advance the scientific quality, sustainability, reproducibility, and translatability of preclinical mouse tumor research.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2025-POC
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
69120 Heidelberg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.