Objective
Parkinson's disease (PD), a highly incapacitating neurodegenerative condition of complex and multifactorial origins, remains incurable. As PD cases have skyrocketed by circa 160% since 1990, the burden on society grows heavier. The lack of reliable systems to test new therapeutics, allied with the limitations of current animal gold standard models, have eluded the development of safe and efficacious molecules to fight PD.
ReMAP-PD aims at validating a novel 3Rs Microphysiological Alternative Platform for testing new therapeutics against Parkinson’s Disease based on a New Approach Methodology (NAM): a next-generation, human-based cellular disease model - fully aligning with the 3Rs principle of replacing, reducing and refining animal testing. Building on a novel microphysiological system, this PoC will deliver a scientifically robust and ethically compliant brain-on-chip platform that emulates key pathological features of PD. By validating this new platform for major in vivo PD cellular and molecular hallmarks, ReMAP-PD presents advantages over other NAMs for PD in terms of: ethical constrains related to cell source and accessibility; reagent costs; technical skills and standardization and user friendliness. With no current robust alternative to test new compounds against PD, ReMAP-PD will not only enhance NAMs translational value but also support a paradigm-shift in disease modelling, accelerating innovation while reducing reliance on animal experimentation.
To unlock ReMAP-PD's innovation potential, we plan to conduct performance metric analysis using a well-characterized panel of drug compounds. Positive outcomes will support EU regulatory submission and attract stakeholder interest, while paving the way for ReMAP-PD IPR protection.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2025-POC
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1099 085 Lisboa
Portugal
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.