Objective
The synthesis of oligonucleotide (oligo) therapeutics presents significant challenges in terms of scalability, cost, and sustainability. Existing methods, such as Solid Phase Oligo Synthesis (SPOS), suffer from low batch sizes, high production costs, environmental concerns, and limited scalability. Consequently, addressing medical conditions affecting large patient populations with oligo therapies remains a formidable task due to our inability to synthesize large batches of pharmaceutical-grade oligos.
Exactmer introduces a groundbreaking solution to this problem through Nanostar Sieving technology. This innovative platform enables large-scale, cost-effective production of precise polymers entirely in solution, overcoming the limitations of traditional solid-phase synthesis methods. By utilizing multi-branched Nanostar hubs and proprietary membranes entirely in liquid phase, Exactmer ensures continuous purification of growing polymers, resulting in large batch production of oligo sequences.
The Nanostar Sieving technology offers unparalleled value to companies in the pharmaceutical industry. It enables the production of large batches of oligos (>50 kg; >5 mol), significantly reducing manufacturing costs by up to 35% compared to traditional methods. Moreover, Exactmer's solution minimizes environmental impact by integrating a membrane-based solvent-recycling loop, aiming to reduce solvent consumption by up to 60%. Under OPToligo, we aim to achieve these goals, improving our Nanostar synthesis process for large-batch oligo production, developing membrane innovation and lower manufacturing costs. Exactmer's Nanostar Sieving technology represents a transformative advancement in oligo synthesis, providing cheaper and more sustainable manufacturing solutions for pharmaceutical companies worldwide.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.3.1 - The European Innovation Council (EIC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-EIC-ACC - HORIZON EIC Accelerator
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-EIC-2025-ACCELERATOR-02
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
HG1 2PW HARROGATE
United Kingdom
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.