Objective
Pathological tissues, such as chronic wounds, carcinogenic burns, and solid tumors, are characterized by a profoundly remodeled extracellular matrix (ECM) that poses a physical barrier to nanomedicine penetration. These environments are further complicated by hostile microconditions, including oxidative stress, acidic pH, enzymatic dysregulation, and chronic inflammation, all of which hinder healing and reduce therapeutic efficacy. Overcoming the formulation challenges and navigating the physiological and immunological barriers within these diseased microenvironments represents a defining frontier for next-generation nanotherapeutics.
HEALSAFE pioneers the development of dynamic, adaptive materials that emulate the responsiveness and intelligence of living tissues. With a strong translational focus and rigorous preclinical validation, HEALSAFE is intended to enhance workforce training and readiness for the era of personalized, responsive medicine.
Key objectives include: (i) Design and synthesis of a modular library of microenvironment-responsive materials and hybrid systems with tunable physicochemical properties for targeted therapeutic applications; (ii) Development and optimization of encapsulation and controlled release mechanisms tailored to complex biological environments; (iii) Evaluation of biocompatibility, safety, and cellular interactions using advanced in vitro 2D and 3D tissue models; (iv) Preclinical demonstration of therapeutic efficacy, biodistribution, and safety in validated in vivo models of wound healing and other relevant pathological conditions; (v) Promotion of international and transdisciplinary collaboration, inter-sectoral knowledge exchange, and capacity building through targeted dissemination and training initiatives. By integrating novel self-assembled stimuli-responsive biomaterials with precision medicine strategies, HEALSAFE sets the stage for transformative advances in nanotherapeutic design and clinical translation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences personalized medicine
- engineering and technology industrial biotechnology biomaterials
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-SE - HORIZON TMA MSCA Staff Exchanges
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-SE-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75794 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.