Objective
Advanced biofabrication approaches have transformed the field of tissue engineering and regenerative medicine, by creating biomimetic tissue grafts to model diseases and to repair and regenerate damaged tissues. The past decade has observed a surge in new in situ approaches that create grafts directly at tissue defect site, allowing anatomical conformity and circumventing the need for invasive implantation. The proposed EchoPrint project presents a significant advancement over state of the art, by introducing a standalone platform technology that leverages acoustic holograms for controlled crosslinking of biomaterials. It will allow deep-tissue or large-volume penetration and enable rapid, single-step fabrication of high-resolution, multiscale constructs in situ.
The EchoPrint apparatus will generate diffraction-limited 3D holographic pressure fields – within in vitro containers and in vivo defect sites – using a novel combination of computationally-optimized phased array transducers and phase maps. New EchoInks will also be developed, comprising naturally-derived or synthetic biomaterials and thermal initiation systems, to enable rapid crosslinking at pressure antinodes within 3D holograms. The analytical framework, multiphysics modeling and key experiments are outlined for fabricating complex structures – metamaterial lattices, filamented hydrogels and perfusable constructs – and assessing scalability, biocompatibility and tissue formation in vitro. Further, ex vivo (cadavers) and in vivo (muscle defects) evaluations will demonstrate preclinical safety and efficacy of the approach. This project leverages my interdisciplinary background and experience developing acoustic field devices and computational models, and biomaterials for engineering tissues such as cartilage and muscle. EchoPrint will drive breakthrough innovations in multidisciplinary science and transform biofabrication by unlocking innovative regenerative strategies and tissue-modeling applications.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology tissue engineering
- natural sciences computer and information sciences computational science multiphysics
- engineering and technology industrial biotechnology biomaterials
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2026-STG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
8092 Zuerich
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.