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Fabricating Interlocked Nanochains with Molecular Machines

Objective

Mechanical manipulation is central to shaping the macroscopic world: from weaving fabrics to tying knots, these operations yield materials with defined form and function. Achieving comparable precision at the molecular scale would open new possibilities in synthetic chemistry, allowing the deliberate construction of interlocked architectures with custom tailored properties.

CATENATOR will apply light-driven molecular machines to assemble monodisperse, sequence-defined and linear [n]catenanes, i.e. molecular architectures made solely from interlocked rings. Currently, no general method exists to access such structures in a precise manner. CATENATOR is thus a realistic proof-of-concept project to explore the potential of artificial molecular machines for the synthesis of an unprecedented class of polymers. The key enabling strategy is Alternating Mechanical Insertion (AMI): a stepwise, machine-directed threading process in which the growing chain is transferred between two anchoring sites of a light-driven molecular motor, adding one ring per cycle. By selecting the macrocycle introduced at each step, AMI enables the precise encoding of complex, non-repetitive and mechanically interlocked sequences. Beyond establishing a new synthetic methodology, CATENATOR will provide access to a previously unexplored class of topologically complex macromolecules. Their mechanically bonded backbones are expected to exhibit distinctive combinations of flexibility, robustness and dynamic response, offering new opportunities in functional molecular design and advanced polymer research.

The successful realization of CATENATOR will redefine what artificial molecular machines can achieve, establishing them as practical synthetic tools and opening new directions in molecular topology, organic chemistry and polymer science.

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Programme(s)

Topic(s)

Funding Scheme

HORIZON-ERC - HORIZON ERC Grants

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Call for proposal

(opens in new window) ERC-2026-STG

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Host institution

HUMBOLDT-UNIVERSITAET ZU BERLIN
Net EU contribution
€ 1 489 071,00
Address
UNTER DEN LINDEN 6
10117 Berlin
Germany
Region
Berlin Berlin Berlin
Activity type
Higher or Secondary Education Establishments
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Total cost
€ 1 489 071,00

Beneficiaries (1)