Objective
Epilepsy is a common neurological disorder characterized by recurrent seizures. Treatment is typically trial-and-error and may take years before seizure control is achieved. The pathophysiology of epilepsy is poorly understood and the clinical diversity is striking. This makes it difficult to predict how a patient will respond to medication, which poses major challenges for treatment prognosis.
The advent of human induced pluripotent stem cells allowed the phenotype, molecular abnormalities, and drug responses of epilepsy to be investigated in vitro in a patient-specific manner. However, little is known about how to translate these in vitro findings to humans, so there is a big gap between clinical practice and research in epilepsy.
The main goal of this project is to close that gap – to enhance the prediction of personalized treatment in epilepsy by translating findings from in vitro models to patients. To achieve this, I will develop a multi-level strategy “from neuron, to network, to brain”, in which clinical features, neuronal network phenotypes, and single-cell abnormalities can be studied for individual patients. I will characterize the phenotype and response to medication at these different levels of complexity and will use digital twin approaches to bridge the information between the levels by unraveling cellular mechanisms underlying network and brain dynamics. For each individual patient, I will identify biomarkers for treatment prediction by defining the cellular mechanisms that correlate at the different levels. This approach will show how relevant in vitro findings are to patients. It ultimately will allow individual phenotypes to be investigated and treatment efficacy to be estimated in vitro, with a reliable translation of findings to the patient. If successful, this bioengineering tool will help to reduce the burden of drug screening for patients and will significantly improve treatment.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project has not yet been classified with EuroSciVoc.
Be the first one to suggest relevant scientific fields and help us improve our classification service
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2026-STG
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
16126 GENOVA
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.