Objective
Patients with acute stroke experience sudden, debilitating symptoms such as loss of speech or motor function, with an estimated loss of 100 million neurons per hour. Beyond recanalization therapy–available to only a minority of cases–our ability to intervene is limited by large gaps in our understanding of human stroke biology. Despite promising experimental insights, few mechanisms or treatments have been successfully translated into clinical practice. This particularly applies to the acute phase when the initial ischemic core evolves into the final infarct and cytoprotective strategies would have greatest impact yet have yielded neutral trial results. With SURPASS, I aim to map human stroke biology at an unprecedented molecular depth and temporal resolution to advance clinical care. By leveraging a combination of deep profiling, ultrasensitive single-molecule detection methods, and highly complementary, multi-national cohorts, I will define clinically relevant molecular signatures for acute stroke across all stages of biomarker development. Specifically, I will: i) discover novel biomarkers by exploring the global circulating proteome and metabolome at hourly resolution within the critical first 48 hours of stroke, when most neurons die, ii) validate and extend these findings in independent, large cohorts, including a global clinical trial, and iii) translate into clinical practice by establishing ultrasensitive point-of-care testing for continuous monitoring of brain injury using DNA-origami-based nanoparticles. By linking serial molecular data with longitudinal neuroimaging and deep clinical phenotyping, I will determine molecular signatures for outcome-relevant mechanisms that allow to stratify patients across biological stroke subtypes, ultimately developing a molecular classification of stroke with therapeutic implications. SURPASS will transform our conceptualization of human acute ischemic stroke, bridge the translational gap, and improve patient care.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project has not yet been classified with EuroSciVoc.
Be the first one to suggest relevant scientific fields and help us improve our classification service
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2026-STG
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
80539 Planegg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.