Objective
ABIGAIL4D pioneers a new approach to personalised oncology by developing and validating a 4D Generative AI system prototype that can learn disease evolution over time and support safer, more informed treatment decisions in early breast cancer. Today, decision support tools rely on static or single-modality data and cannot estimate how an individual patient would respond to alternative therapies. This limits clinical ability to compare options and optimise outcomes.
ABIGAIL4D combines multimodal longitudinal data, including imaging, pathology, genomics, and clinical variables, into a temporal model that reconstructs and forecasts tumour response, survival and toxicity. The system introduces counterfactual analysis to estimate patient-specific benefit and risk for different treatment strategies, such as escalation and de-escalation of chemotherapy or radiotherapy. Specialised AI agents (Radiology, Pathology, Oncology and Patient) collaborate through a stateful orchestrator to generate explainable recommendations with quantified uncertainty. Clinicians remain in control at all times, supported by transparent rationales linked to clinical concepts and guidelines.
The methodology follows a staged design: requirements co-creation with clinicians; development of the GenAI backbone and multi-agent framework; trust-by-design mechanisms for traceability, reproducibility and explainability; and validation in controlled, multi-centre lab settings. Regulatory documentation aligned with EU Medical Device Regulation and the AI Act will support future certification.
ABIGAIL4D AI agents and system, aim at enabling in the future personalised treatment decisions and more efficient care pathways. Expected benefits will include better therapy selection, fewer unnecessary scans and reduced burden for patients and healthcare systems. ABIGAIL4D provides a foundation for future expansion to other solid tumours, contributing to Europe’s leadership in responsible AI driven precision medicine
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- medical and health sciences clinical medicine oncology breast cancer
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.3.1 - The European Innovation Council (EIC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-EIC - HORIZON EIC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-EIC-2025-PATHFINDERCHALLENGES-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
08290 Cerdanyola Del Valles (Barcelona)
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.