Objective
INPROBED pioneers a paradigm shift in plant biotechnology by moving from conventional gene editing to precision promoter engineering, by adapting natural gene regulation to build stress resilience and nutritional quality into food crops. The project will develop the first predictive “promoter design platform” for tomato, integrating single-cell MOA-seq with deep-learning models to map and reprogram cis-regulatory elements that control plant responses to heat, drought, and micronutrient limitation. This approach enables precise, predictable, and regulation-compatible genome edits that enhance resilience without compromising growth or yield.
Using CRISPR-based promoter editing, INPROBED will generate tomato lines that accumulate more zinc, iron, and provitamin D₃ while maintaining stable performance under stress. These lines will be validated through multi-omics analysis and high-throughput phenotyping, resulting in pre-breeding of proof-of-concept lines for semi-field trials.
The consortium unites world-leading expertise in genomics, cistromics, and translational crop science: Heinrich Heine University advances promoter discovery and single-cell analysis; Wageningen University and the Weizmann Institute lead nutritional and metabolic engineering; KeyGene leads the genome editing, single cell technology development and ensures rapid integration into breeding pipelines; and PLANeT Biotech drives phenotyping, validation, and commercialization.
INPROBED is a generic technology platform enabling crop improvement via rational promoter engineering in a crop-agnostic manner.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology genetic engineering gene therapy
- natural sciences earth and related environmental sciences environmental sciences sustainability sciences
- natural sciences physical sciences astronomy planetary sciences planets
- agricultural sciences agriculture, forestry, and fisheries agriculture agronomy
- natural sciences biological sciences genetics genomes
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.3.1 - The European Innovation Council (EIC)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-EIC - HORIZON EIC Grants
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-EIC-2025-PATHFINDERCHALLENGES-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
6700AE Wageningen
Netherlands
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.