Objective
GLIOGEN-X pioneers a new paradigm in neuro-oncology. It is a novel generative AI modality designed to test whether brain MRI truly encodes recoverable molecular information about gliomas. While current radiogenomic approaches assume that deep networks can implicitly learn tumour biology from images, this project transforms that assumption into a falsifiable hypothesis, experimentally probing the informational limits of MRI and its capacity to support virtual biopsy.
The project builds on three synergistic, high-risk/high-gain pillars. First, generative experimentation will use controlled diffusion models to synthesise realistic, biomarker-aware glioma MRIs, testing whether molecular conditioning injects measurable and reproducible phenotypic structure. Second, interpretable and uncertainty-aware prediction will translate these generative insights into transparent virtual-biopsy models, capable of identifying key molecular signatures from imaging alone.
Third, a federated research infrastructure will ensure privacy-preserving, GDPR-compliant collaboration across hospitals, enabling robust validation without data sharing and fostering reproducibility.
Beyond its scientific objectives, GLIOGEN-X establishes the methodological and ethical foundations for AI Act–ready medical AI: explainable, auditable, and human-centred by design.
Its outputs, a pathology-aware generative engine, hybrid datasets, interpretable predictors and an experimental research platform, will form a reusable European asset for trustworthy AI in healthcare.
Whether confirming or refuting the central hypothesis, GLIOGEN-X will deliver transformative knowledge by defining how far imaging can reveal tumour biology and paving the way for non-invasive, personalised oncology guided by trustworthy artificial intelligence.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences artificial intelligence
- medical and health sciences clinical medicine oncology
- engineering and technology medical engineering diagnostic imaging magnetic resonance imaging
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.3.1 - The European Innovation Council (EIC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-EIC - HORIZON EIC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-EIC-2025-PATHFINDERCHALLENGES-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
53100 Siena
Italy
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.