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Target mining for the development of therapeutics against pathogen-induced cancers

Objective

Gastrointestinal cancers, including gastric and colorectal cancer, are among the most prevalent and lethal malignancies worldwide. Growing evidence highlights the microbial agents Fusobacterium nucleatum, Helicobacter pylori, or Epstein-Barr Virus as prominent key drivers of cancer initiation and progression by disrupting epithelial signaling, promoting chronic inflammation, and evading immune surveillance. However, current therapeutic strategies and model systems rarely address pathogenic tumorigenesis or progression and altered drug efficacy in the presence of these pathogens, leaving a critical gap in the development of precise and preventive treatments.
TagTIC addresses this challenge through a systems medicine approach that integrates microbiology, cancer biology, drug discovery, and artificial intelligence. By using innovative preclinical organoid model systems that closely resemble patient conditions, TagTIC aims to decipher complex host-pathogen interactions at single-cell and spatial resolution and to address them therapeutically. Research will focus on: (i) identifying vulnerable molecular nodes involved in pathogen-associated cancers; (ii) developing novel strategies for lead discovery and treatment; (iii) generating and analyzing innovative ex vivo models using 2D/3D cultures, patient-derived organoids, and organ-on-chip technologies. The network will train eleven Doctoral Candidates (DCs) towards translational leaders, capable of analyzing and solving complex biomedical needs with innovative strategies and approaches.
DCs will follow a structured training program combining basic and translational science with cross-sectoral exposure to academia and industry. The collaboration between nine beneficiaries and 14 associated partners ensures a strong curriculum, interdisciplinary mentorship, and international mobility to empower DCs for careers in academia, biotech, pharma, and socio-economic sectors across Europe.

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Keywords

Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)

Programme(s)

Multi-annual funding programmes that define the EU’s priorities for research and innovation.

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

HORIZON-TMA-MSCA-DN-JD - HORIZON TMA MSCA Doctoral Networks - Joint Doctorates

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) HORIZON-MSCA-2025-DN-01

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Coordinator

PARIS-LODRON-UNIVERSITAT SALZBURG
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 806 781,12
Address
KAPITELGASSE 4-6
5020 Salzburg
Austria

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Region
Westösterreich Salzburg Salzburg und Umgebung
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

No data

Participants (8)

Partners (14)