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Equitable musculoskeletal health driven by inclusive models

Objective

Musculoskeletal (MSK) disorders are a leading global cause of disability, affecting people of all demographics (age, gender, ethnicity…) and contributing significantly to reduced quality of life, loss of productivity and healthcare costs. The complexity of their pathophysiology across scales eludes healthcare professionals, and treatments remain mostly palliative with predominantly one-size-fits-all approaches. As the concept of digital twins in health develops, in silico modelling and simulation provides unique opportunities to integrate heterogeneous information coherently, for precise stratification and targeted treatment and prevention. However, and despite the broad impact of MSK disorders, the models simulating MSK function and disease remain largely derived from homogeneous data biased, as per sex, age, health status, and ethnics. This lack of diversity limits applications in precision medicine and risks reinforcing systemic healthcare inequities in diagnosis and treatment.

The EDI-MSK MSCA Doctoral Network aims to train a new generation of professionals in in silico medicine with expert culture and skills to include diversity at the core of model developments for MSK health and disease, across scales. Specifically, by using data from experiments, and from population and patient cohorts, stratified by sex, age, and co-morbidities, also integrating social sciences and coproduction with communities, the DN will uniquely define diversity hallmarks to be incorporated into MSK models. It will generate and test methodological blueprints to incorporate life habits, sex, including women’s health, age, rare and chronic disease, and ethnicity. The EDI-MSK consortium includes seven beneficiaries and 13 associated partners. It benefits from the experience of non-profit institutions and SME that are significant players in the in silico medicine ecosystem and will make the EDI-MSK Doctoral Candidates become leaders of the transformation of MSK model towards inclusivity.

Fields of science (EuroSciVoc)

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Keywords

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Programme(s)

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Topic(s)

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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks

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Call for proposal

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(opens in new window) HORIZON-MSCA-2025-DN-01

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Coordinator

UNIVERSITY OF LEEDS
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 1 394 952,48
Address
WOODHOUSE LANE
LS2 9JT Leeds
United Kingdom

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Region
Yorkshire and the Humber West Yorkshire Leeds
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

No data

Participants (6)

Partners (13)

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