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Metabolic disease heterogeneity definition, prevention and remission with targeted interventions

Objective

Obesity, diabetes and associated complications constitute a rapidly escalating scientific and societal challenge across Europe marked by profound heterogeneity in causes, clinical trajectories and treatment responses. This heterogeneity explains the limited effectiveness of standardized therapies and highlights the need to stratify metabolic disease. To confront this challenge, MEDIculous REMeDy brings together a pan-European, interdisciplinary doctoral network spanning academia, healthcare, industry, public and patient organizations. The network’s first objective is to train critical and entrepreneurial metabolic health researchers through innovative interdisciplinary, translational and intersectoral training focused on tailored career development, transferable skills and leadership. Gender-responsive research design, open science, public and patient engagement underpin this training culture, equipping DCs with essential skills for academic and non-academic careers. These early-career researchers will drive – and be shaped by – our scientific objectives: (1) to map metabolic disease heterogeneity across the full disease spectrum from early metabolic dysfunction and obesity to advanced diabetes with complications, and (2) to dissect this heterogeneity from underlying molecular mechanisms to biomarkers, therapeutic targets and treatment responses. To achieve its scientific objectives, the consortium will integrate metabolic medicine and computational systems biology that draw on multi-country European patient cohorts, advanced human in vitro platforms and complementary in vivo disease models. This novel integrative strategy enables the development of robust patient stratification and personalized therapeutic approaches applicable across European populations, pushing precision medicine forward. By uniting scientific excellence, pioneering training and societal relevance, MEDIculous REMeDy transforms metabolic disease research and precision medicine across Europe.

Fields of science (EuroSciVoc)

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Keywords

Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)

Programme(s)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) HORIZON-MSCA-2025-DN-01

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Coordinator

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 580 544,64
Address
INGOLSTADTER LANDSTRASSE 1
85764 Neuherberg
Germany

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Region
Bayern Oberbayern München, Landkreis
Activity type
Research Organisations
Links
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

No data

Participants (11)

Partners (19)