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Vaccinologists for Europe: Training network for developing next generation vaccines against mucosal pathogens

Objective

"AntimicrobiaAntimicrobial resistance (AMR) and emerging viral pathogens pose significant global health threats, with mucosal infections contributing to severe morbidity and mortality. Current systemic immunization strategies fail to induce effective mucosal immunity, including tissue-resident memory cells (TRMs) and secretory IgA (sIgA). Addressing this gap requires targeted research and training in mucosal vaccinology. The Vax4eU network aims to advance next-generation mucosal vaccines through a multidisciplinary program for 16 Doctoral Candidates (DCs), focusing on vaccine candidates and technologies that induce robust mucosal immunity, prevent infection, and combat AMR.
Vax4eU integrates cutting-edge approaches, including AI-assisted antigen design, novel adjuvants, and tailored nanoparticle delivery systems. Research spans the vaccine pipeline, from drug substance design to preclinical evaluation. Work Package (WP) 1 focuses on antigens and adjuvants, using platforms like mRNA and fusion proteins, along with mucosal-targeting strategies such as ""Blood2Gut"" adjuvants. WP 2 develops advanced delivery systems, including polysaccharide, protein, and lipid nanoparticles and innovative mucosal adjuvants like cyclic dimeric AMP. WP 3 identifies CoIs and CoPs using high-dimensional tools and preclinical models, including pigs, which closely mimic human mucosal immunity.
The program combines research with robust training, offering DCs individualized projects, network-wide training in AI tools, regulatory processes, drug delivery, and preclinical studies. Collaboration with academic and non-academic partners ensures DCs gain insights into scientific and translational aspects of vaccinology, supported by secondments, expert mentoring, and interinstitutional collaboration.
By advancing mucosal vaccine technology and addressing AMR, Vax4eU aligns with European public health priorities, fostering a new generation of skilled vaccinologists to tackle global infectious diseases."

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Keywords

Programme(s)

Topic(s)

Funding Scheme

HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks

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Call for proposal

(opens in new window) HORIZON-MSCA-2025-DN-01

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Coordinator

TECHNISCHE UNIVERSITAET MUENCHEN
Net EU contribution
€ 1 161 089,28
Address
Arcisstrasse 21
80333 Muenchen
Germany
Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Links
Total cost
No data

Participants (10)

Partners (8)