Objective
NEUROMAGIC is set to pioneer a groundbreaking approach in the realm of bidirectional brain-machine interfaces (BBMIs) by creating
Smart Anisotropic Magnetic Nanomaterials (SAMNs) for wireless, precise, and cell-specific neuromodulation in deep brain regions.
This innovative technology circumvents the need for invasive electrode implants, by establishing a minimally-invasive and highly
effective communication channel with neurons. By exploiting the unique properties of SAMNs, engineered through the doping of
anisotropic magnetite nanoparticles with divalent transition metals, NEUROMAGIC will to significantly enhance vortex magnetization,
facilitating the conversion of magnetic fields into mechanical torques that can trigger neuronal excitation via calcium influx, thereby
enabling precise monitoring and modulation of neural activity. We will employ advanced polymer and biomolecule
functionalization techniques to endow SAMNs with dual capabilities: target specific neuronal populations and read out neural activity
through calcium signaling. This will be achieved by integrating a calcium-specific protein for direct MRI-based detection of neural
activity and by functionalizing SAMNs with genetic material and antibodies to achieve cell-type specificity. NEUROMAGIC will
leverage an Integrated Computational Materials Engineering (ICME) framework, incorporating text-mining, NLP, and predictive modeling, to optimize the magnetic properties of SAMNs, ensuring their effective passage through the blood-brain barrier and proximity to neuron
membranes. A novel controller system based on reinforcement learning will enable real-time, adaptive neuromodulation tailored to
individual physiological responses. This approach promises to revolutionize the field of BBMIs, offering a versatile platform for both
research and therapeutic applications, with the potential to transform the treatment landscape for a range of neurological and
psychiatric disorders.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-DN-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
00133 Roma
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.