Objective
TIE2gether is a multidisciplinary research and training network addressing major unmet needs in vascular medicine.
A wide range of vascular-related diseases—including chronic kidney disease, diabetic vasculopathy, sepsis, glaucoma and vascular malformations—affects millions and imposes a major societal and economic burden. Yet these conditions still lack effective, mechanism-based therapies. A unifying feature across these clinically distinct diseases is dysregulation of the TIE2 signalling cascade: hyperactivation drives vascular malformations while insufficient activity causes vascular leak, inflammation and organ dysfunction. Restoring balanced TIE2 signalling thus represents a major, largely unexplored therapeutic opportunity with relevance across both common and rare diseases.
TIE2gether translates this opportunity into real-world benefit by training a new generation of scientists capable of bridging fundamental discovery with therapeutic innovation. The network brings together leading experts in vascular biology, organ-on-chip technologies, advanced disease modelling, chemical biology, protein engineering, and drug discovery. By centring around a single, highly druggable pathway, TIE2gether creates strong synergy and accelerates the transfer of mechanistic insight into validated therapeutic strategies evaluated in human-relevant systems.
Fourteen Doctoral Candidates will gain cutting-edge competences in dissecting TIE2 signalling mechanisms, developing state-of-the-art disease models and designing and assessing next-generation therapeutics, including network-developed drug leads. Complemented by interdisciplinary, clinical and patient-facing training, they will acquire the innovation mindset, translational expertise and transferable skills needed across academia, industry and the biomedical sector. TIE2gether will deliver skilled researchers and novel therapeutic concepts to advance targeted treatments for vascular diseases with major societal impac
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-DN-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
00014 Helsinki
Finland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.