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Automated Organoid Screening Platform For Drug Discovery and Precision Medicine

Objective

The project addresses Challenge 2 of the European Innovation Council Advanced Innovation Challenges Pilot by advancing a disruptive New Approach Methodology (NAM) platform designed to accelerate cancer drug development while reducing reliance on exploratory animal experimentation.
OKOMERA’s Ocentra platform is a compact, automated benchtop system integrating rapid 48-hour three-dimensional organoid generation from minute patient-derived tumor samples with automated microfluidic standardization and AI-driven analytics in a single industrial workflow. Unlike existing organoid platforms relying on manual multiwell expansion and fragmented processes, Ocentra enables standardized, miniaturized, and traceable generation of uniform tumor microtissues. This directly addresses a major barrier to NAM adoption: the lack of reproducible and transferable systems compatible with pharmaceutical R&D environments.
The prototype has been validated in-house using multiple patient-derived tumor models, demonstrating reliable automated 3D culture formation and reproducible compound exposure suitable for target validation and quantitative dose-response profiling.
The EIC AIC Stage 1 project will conduct the first independent validation of the prototype in an external pharmaceutical research laboratory to assess robustness, reproducibility and operational feasibility outside the developer’s facilities. In parallel, the project will implement a robust data governance framework ensuring traceability and regulatory-aligned handling of patient-derived biological materials, and define a Stage 2 transition strategy including a regulatory and commercial adoption roadmap and formalized commitments from industrial and clinical partners to support continued validation and pilot activities.

Fields of science (EuroSciVoc)

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Keywords

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Programme(s)

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Topic(s)

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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

HORIZON-EIC - HORIZON EIC Grants

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Call for proposal

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(opens in new window) HORIZON-EIC-2026-AIC

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Coordinator

OKOMERA
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 300 000,00
Address
9bis rue d'Alembert
75014 Paris
France

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Ile-de-France Ile-de-France Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Links
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

No data