Objective
Dysglycaemia affects 75% of critical care patients and increases 30-day mortality up to fivefold. Glucose clamping at normoglycaemia reduces mortality by 29%, serious infections by 53%, and major cardiovascular events by 43%, but has never entered clinical practice because no reliable real-time intravascular glucose sensor has existed. GlucoClamp is the first automated closed-loop glucose control system designed for critical care: an intravascular optical sensor placed through an existing arterial catheter feeds real-time glucose values into a software controller that adjusts IV glucose infusion automatically, while insulin remains under nurse control.
CLICC is a 22-month project advancing GlucoClamp from TRL 6 to TRL 8 with five objectives: (1) transfer sensor manufacturing to a qualified contract manufacturer and validate a scalable production process; (2) finalise and freeze IEC 62304-compliant GlucoClamp software; (3) complete MDR-compliant validation including a first-in-human closed-loop clinical investigation in 30 cardiac and abdominal surgery patients; (4) compile the full MDR Annex II/III technical file for CE-mark submission; and (5) protect foreground IP via 3 PCT applications, confirm FDA 510(k) and PMDA regulatory pathways, and secure a signed commercial agreement with the identified pilot customer.
An EIC grant of EUR 2.5M de-risks the EUR 19M private investment needed for subsequent market entry across EU, US and Japan, directly serving the EIC Work Programme priority for breakthrough medical technologies with proven clinical benefit and scalable commercial impact.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography mortality
- medical and health sciences clinical medicine surgery
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors optical sensors
- medical and health sciences clinical medicine critical care medicine
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance multidrug resistance
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.3.1 - The European Innovation Council (EIC)
MAIN PROGRAMME
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HORIZON.3.1.2 - The Accelerator
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-EIC-ACC - HORIZON EIC Accelerator
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-EIC-2026-ACCELERATOR-02
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
7037 Oslo
Norway
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.