Objective
Autoimmune diseases (AD) affect 1 in 10 people and cost the EU €57.2B annually. Antibody-mediated ADs share a common driver: a rare population of autoreactive B-cells that produce pathogenic autoantibodies. Current treatments rely on broad immunosuppression, which only manages symptoms transiently while leaving patients dependent on lifelong medication and at risk of serious infections.
Canopy’s proprietary Antigen-Drug-Conjugate (AgDC) platform introduces the first non-immunosuppressive, mechanism-based therapeutic approach capable of delivering durable remission. AgDCs combine two independent mechanisms: (1) rapid sequestration of pathogenic autoantibodies and (2) targeted elimination of the autoreactive B-cells producing them. Unlike current treatments, this dual activity preserves protective immunity while addressing the root cause of disease. The platform’s modular design allows rapid adaptation across multiple ADs by varying only the engineered autoantigen component.
The project aims to clinically validate MGAC-007, a potentially curative therapy for Myasthenia Gravis (MG). MG is a chronic, life-threatening disease affecting ~10 per 100,000 people in Europe. We will execute a Phase I clinical study at Charité–Universitätsmedizin Berlin, targeting Acetylcholine Receptor (AChR) Positive patients. Supported by the Charité Research Organisation and a network of 22 MG centres, the trial will assess safety, pharmacokinetics, and early biological activity. In parallel, a validated consortium of CDMOs will manufacture GMP-grade drug substance, ensuring a clear path to scale-up.
MGAC-007 addresses a TAM projected to reach €34B by 2035. Beyond MG, the AgDC platform has the potential to treat ~895,000 patients globally each year. By replacing chronic immunosuppression with targeted, curative therapies, Canopy will reduce long-term healthcare expenditure and dramatically improve quality of life for populations disproportionately affected by autoimmune disorders.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project has not yet been classified with EuroSciVoc.
Be the first one to suggest relevant scientific fields and help us improve our classification service
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.3.1 - The European Innovation Council (EIC)
MAIN PROGRAMME
See all projects funded under this programme -
HORIZON.3.1.2 - The Accelerator
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-EIC-ACC - HORIZON EIC Accelerator
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-EIC-2026-ACCELERATOR-02
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
3087500 Megadim
Israel
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.