Objective
Cardiovascular disease (CVD) remains the leading cause of death in Europe. Many fatal events are preventable through better management of indirect risk factors. Obesity promotes metabolic disturbances, including hypertension and diabetes, while also disrupting autonomic nervous system regulation and increasing cardiovascular risk. Baroreflex impairment, arrhythmias and nocturnal blood pressure dysregulation are overt signs of Parkinson’s disease and create conditions for sudden cardiac death. Sleep disorders, such as periodic limb movements, trigger repeated nocturnal sympathetic surges, increasing long-term cardiovascular risk and potentially signaling prodromal neurodegeneration. Despite their differences, obesity, Parkinson’s disease, and periodic limb movements converge on autonomic dysfunction as a key mechanism linking them to CVD. Nonetheless, understanding dynamic autonomic regulation requires advanced analytical approaches. In the emerging research field of Network Physiology, data-driven tools model organ systems as interconnected nodes, capturing high-order interactions beyond traditional pairwise analyses and thus allowing quantification of collective dynamics among multiple systems. Building on a Network Physiology approach, this project will advance methodology by integrating time series modelling, information theory, and dynamic system analysis, and leverage a network-based perspective to (1) assess high-order interactions in physiological systems and characterize autonomic regulation across health and disease, (2) explore central-autonomic contributions to CVD-related complications, and (3) derive clinical markers for risk prediction and therapeutic targeting. By integrating network science with clinical research, the project aims to uncover mechanisms of autonomic dysfunction and enable early interventions to reduce preventable CVD deaths.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine psychiatry sleep disorders
- natural sciences biological sciences neurobiology
- medical and health sciences clinical medicine cardiology cardiovascular diseases cardiac arrhythmia
- medical and health sciences basic medicine physiology
- medical and health sciences health sciences nutrition obesity
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.4.1 - Widening participation and spreading excellence
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-WIDERA-2025-TALENTS-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
814 99 BRATISLAVA 1
Slovakia
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.