Objective
Antibacterial resistance represents a major and growing threat to global public health, while the development of new antibiotics with novel mechanisms of action has largely stagnated. The SIDEROSENSE project addresses this challenge by advancing a fundamentally new antibacterial modality based on antisense technology. SIDEROSENSE enables selective intracellular delivery of antibacterial antisense oligonucleotides, overcoming a long-standing barrier to the clinical translation of antisense-based antibacterials. Proof-of-principle studies have demonstrated potent antibacterial activity.
This ERC Proof of Concept project aims to establish whether the SIDEROSENSE technology translates into a safe and effective antibacterial strategy. The project will generate critical experimental data, while simultaneously strengthening the IP position and assessing regulatory and commercial pathways. In parallel, a market and exploitation strategy will be developed to support informed go/no-go decisions and downstream translation. SIDEROSENSE will deliver the essential technical and strategic validation required to assess the feasibility of antisense-based antibiotics as a new therapeutic class and to position the technology for subsequent translational funding and clinical development.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2026-POC
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
6525 XZ Nijmegen
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.