Objective
Tooth loss and the resulting alveolar bone resorption are highly prevalent conditions, particularly in aging populations and in patients suffering from inflammatory periodontal diseases. Dental implants are the preferred solution for replacing missing teeth; however, successful implantation requires sufficient alveolar bone volume. Bone resorption frequently leads to unfavorable conditions of the alveolar ridge, making socket preservation and bone augmentation procedures necessary to regenerate sufficient bone volume prior to dental implant placement. Current bone grafting approaches remain limited, particularly in elderly patients, diabetics, and smokers, highlighting the urgent need for improved regenerative strategies.
Here, we aim to develop a novel alveolar bone graft based on our patent-protected polysaccharide-peptide composite hydrogel, developed within the PersonalBone ERC-StG project. Unlike conventional bone graft materials, which primarily function as osteoconductive scaffolds, our technology is designed as an osteoinductive, immune-instructive biomaterial that actively recruits and modulates the host immune response to promote bone regeneration. By creating a bioactive microenvironment that stimulates immunomodulation and osteogenesis, this material represents a paradigm shift in alveolar bone regeneration strategies.
Within this ERC-PoC project, we will optimize the hydrogel formulation to achieve the mechanical stability required for socket preservation and its integration with clinically used bone graft particulates. The optimized composite graft will be evaluated for biocompatibility, bone regeneration capacity, and resorption kinetics in critical-size bone defect models in vivo, with clinical input from leading dentists. This technology has the potential to significantly advance current bone augmentation treatments and improve clinical outcomes for patients requiring dental implants.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2026-POC
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
69978 Tel Aviv
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.