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CORDIS - Résultats de la recherche de l’UE
CORDIS

Twinning Workforce for Innovation, Scientific Transformation and Capacity Building IN Advanced DruG Discovery

Objectif

Drug discovery research includes lengthy Design-Make-Test-Analyze (DMTA) cycles that can delay the development and clinical trials of novel drug candidates by months, or even years, if not conducted efficiently. Not only the length of such DMTA cycles, but also flawed collaboration infrastructure between various leading European drug discovery institutes hampers drug discovery timelines, eventually resulting in more patients with serious diseases left untreated.
The TWISTING project aims to leverage on the drug discovery capacity of two widening institutions, University of Patras (UPAT, GR, Coordinator) and National Institute of Research and Innovation (NIRI; former Latvian Institute of Organic Synthesis, LV), based on the excellence of two leaders in the field, ETH Zurich (CH) and University of Oulu (UOULU, FI), to address lengthy DMTA cycles and inefficient drug discovery infrastructures by the WIDERA ‘twinning’ exercise. In addition, NexMR (CH) will join as a young startup to warrant effective valorization of scientific project results, as well as strengthening engagement with pharmaceutical companies and other industrial stakeholders.
Through twinning actions in the project, such as knowledge transfer and short-term staff exchanges, main applicant UPAT and widening partner NIRI will increase their scientific excellence, global network and infrastructure to the highest standards of advanced partners UOULU and ETHZ. Collectively, the partners will implement measures to improve research management, fundability and dissemination strategies for the widening partners. To validate the newly established research infrastructure, the partners will conduct a mutual drug discovery project on protein-protein interaction (PPI)-centric drug discovery with >80% shorter and more effective DMTA cycles.
The results of this project are preclinical drug candidates for difficult PPI-centric targets in the field of oncology, autoimmune diseases or neurodegenerative diseases with a potentially life-saving impact. The non-scientific project results include capacity-building for research infrastructure at widening partners UPAT and NIRI, transforming them into globally-leading academic institutes for advanced drug discovery.
In the long-term, the project is expected to result in significant expertise, employment growth and a renowned international reputation for the widening partners in the context of drug discovery and Life Sciences. This will set the foundation for a Pan-European research collaboration network for advanced drug discovery, with each partner bringing unique expertise and infrastructure to discover new small molecule drugs for diseases with high unmet needs and leverage the human potential and the institutional capacity of the widening partners.

Champ scientifique (EuroSciVoc)

Mots‑clés

Programme(s)

Thème(s)

Régime de financement

HORIZON-CSA - HORIZON Coordination and Support Actions

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Appel à propositions

(s’ouvre dans une nouvelle fenêtre) HORIZON-WIDERA-2026-02

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Coordinateur

PANEPISTIMIO PATRON
Contribution nette de l'UE
€ 600 133,10
Adresse
UNIVERSITY CAMPUS RIO PATRAS
265 04 RIO PATRAS
Grèce
Région
Κεντρική Ελλάδα Δυτική Ελλάδα Αχαΐα
Type d’activité
Higher or Secondary Education Establishments
Liens
Coût total
Aucune donnée

Participants (4)