Objective
"Triple-Negative Breast Cancer (TNBC) remains one of the most challenging subtypes of oncology due to its high metastatic potential, lack of targeted receptors, and rapid development of drug resistance. The BioMIX project proposes a disruptive solution: a ""stealth"" biomimetic nanoplatform designed to bypass the immune system and deliver a potent combination of chemotherapy, gene therapy, and sonodynamic therapy (SDT) directly to the tumor site. The core of the BioMIX technology is a two-dimensional Ti3C2 MXene nanosheet, which serves as a structural scaffold and a high-efficiency sonosensitizer. This core is functionalized with a pH-responsive polydopamine shell to entrap Doxorubicin and a cationic layer to complex anti-MDR1 siRNA. To achieve superior targeting, the construct is ""camouflaged"" with a hybrid membrane fused from TNBC cells and macrophages, further enhanced with iRGD peptides for deep-tissue penetration. Upon reaching the tumor, low-intensity ultrasound is applied to trigger localized hyperthermia and reactive oxygen species (ROS) generation, causing controlled drug release and inducing targeted cancer cell apoptosis. As an MSCA Staff Exchange action, BioMIX is built on a highly interdisciplinary consortium of 13 international partners across the academic and industrial sectors. The project is structured to facilitate more than 200 person-months of knowledge transfer, conveying critical expertise in 2D materials science, microfluidic manufacturing, and preclinical oncology research. By integrating ""Tumor-on-a-Chip"" validation and in vivo efficacy studies, BioMIX aims to establish a clinically translatable framework for targeted nanomedicine while reducing the systemic side effects (such as cardiotoxicity) of conventional chemotherapy. The project’s outcomes will strengthen European leadership in nanobiotechnology and provide a scalable framework for the next generation of biomimetic therapeutic vehicles aligned with Europe’s Beating Cancer Plan."
Fields of science (EuroSciVoc)
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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HORIZON.1.2.3 - Strengthening Human Resources and Skills Development across the European Research Area
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-SE - HORIZON TMA MSCA Staff Exchanges
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2026-SE-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1586 RIGA
Latvia
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.