Objective
Cardiovascular disease (CVD) remains the leading cause of mortality in Europe, driven by unresolved vascular inflammation and the lack of mechanistically grounded biomarkers. INNOVATOC addresses this challenge by investigating perivascular adipose tissue (PVAT) as a key regulator of vascular inflammation and plaque instability through a structured programme of international, intersectoral and interdisciplinary knowledge exchange.
The project will generate a unique cross-species PVAT–plaque multi-omics dataset from human tissues and complementary animal models. Integrated analysis, supported by single-nuclei RNA sequencing, will enable identification and prioritization of mediators involved in PVAT–vascular crosstalk and inflammation resolution, followed by functional validation in advanced adipocyte–vascular–immune interaction systems.
INNOVATOC will deliver: 1) prioritised panel of 15 candidate biomarkers (miRNA, protein and specialised pro-resolving lipid mediators, SPLM), 2) validated LC–MS/MS-based assay for targeted SPLM quantification, designed for scalability and clinical applicability, 3) novel organ-on-chip (OoC) prototype that recapitulates PVAT–vascular interactions under physiologically controlled conditions. These outputs will support the establishment of a predictive biomarker panel for cardiovascular risk prediction, validated in well-characterised clinical cohorts.
Through structured secondments and joint activities, INNOVATOC will enable intensive knowledge transfer across disciplines and sectors, fostering innovation in biomarker discovery, analytical technologies, and organ-on-chip systems. The consortium brings together 6 academic institutions, 5 non-academic partners (including 2 SMEs and 3 clinical centres), and 1 international associated partner, ensuring balanced expertise across research, clinical translation, and technological development, and supporting sustainable long-term collaboration networks.
Fields of science (EuroSciVoc)
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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HORIZON.1.2.3 - Strengthening Human Resources and Skills Development across the European Research Area
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-SE - HORIZON TMA MSCA Staff Exchanges
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2026-SE-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
11010 BELGRADE
Serbia
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.