Objective
In May 2026, a Bundibugyo virus disease (BVD) outbreak was reported in Democratic Republic of Congo (DRC), highlighting the urgent need for effective medical countermeasures, as no licensed vaccine or therapeutic is currently available against this Ebola species. The EBO-PEP project was funded by EDCTP in 2024 to evaluate a post-exposure prophylaxis (PEP) strategy against Ebola virus disease (EVD). Beyond its initial objective, EBO-PEP enabled the consortium to establish a robust outbreak research platform, designed as a preparedness tool rapidly activatable across filovirus species. The emergence of the current BVD outbreak in Eastern DRC provides the first opportunity to implement this framework. The consortium has adapted the EVD protocol to the BVD context, mobilizing the infrastructure, partnerships, and operational capacities already in place. Among the candidate interventions, obeldesivir (ODV), an orally administered broad-spectrum antiviral prioritized by the WHO R&D Blueprint, is evaluated as PEP in a randomized trial. Remdesivir (RDV), with an established safety profile in children and pregnant women, is proposed for vulnerable populations excluded from the randomized trial. The EBO-PEP consortium brings together African and European institutions with complementary expertise in filovirus research and clinical trial implementation in outbreak settings. The overall objective of this project is to increase the portfolio of therapeutic tools against BDBV by evaluating a PEP strategy for high-risk contacts in Eastern DRC. To address this objective, we focus our activities on two specific objectives: (i) to set up a randomized, placebo-controlled phase III clinical trial in Eastern DRC to test the efficacy of ODV used as PEP for high-risk contacts; and (ii) to set up a parallel prospective interventional cohort to generate evidence on the safety, feasibility, and effectiveness of RDV as PEP in children under 12 years and pregnant or breastfeeding women.
Fields of science (EuroSciVoc)
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.2.1 - Health
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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HORIZON-JU-GH-EDCTP3-2026-01-EBOLA-IBA - HORIZON-JU-GH-EDCTP3-2026-01-EBOLA-IBA: Mobilisation of research funds for the expansion of activities of project EBO-PEP (101145675) in the context of the recent Bundibugyo outbreak in Democratic Republic of the Congo (DRC) and Uganda
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-JU-RIA - HORIZON JU Research and Innovation Actions
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-JU-GH-EDCTP3-2026-01-EBOLA-IBA
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75654 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.