Objective
Function and properties of molecules depend on their three dimensional (stereo) structure. The structure is determined not only by types of atoms and bonds but also by its symmetry and chirality. The last phenomenon concerns the molecules (stereoisomers) w hich remain in the relation object-its mirror image and thus are not superimposable. Stereoisomers exhibit usualy dramatical differences in their biological activity. One stereoisomer can be active drug, the second (mirror image) can possess no activity or be even harmfull (story of Thalidomide). Selection of the appropriate stereoisomer offers therefore benefits of better therapeutical profile of drug and the reduction of the dose and side effects.There is tremendous demand for developing new tools for sep aration stereoisomers either for preparative (production) or for analytical purposes (research, medical studies, quality control). Desiging of new chiral stationary phases for chromatograpic separation meets this demand. The goal of this project is the syn thesis and evaluation of novel, chiral stationary phases. These exhibit many unique features: - are switchable - can adopt their shape to the shapes of analysed molecules (selectands), - contain Cinchona alkaloid molecules which are known for numerous appl ication in organic synthesis as catalysts, resolving agents and single chiral phases. They are also widely available, relatively cheap and non-toxic, - are of C2 symmetry (which is very rare in the common chiral selectors, but very succesfull in the field of stereoselective synthesis and molecular recognition), - have many binding sites crucial for molecular recognition. My preliminary studies showed that compunds of this group efficiently recognize either achiral or chiral molecules. Based on these results and results obtained by host, it can be anticipated that these selectors when supported can serve as novel, efficient stationary phases for either chiral or achiral recognition.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences polymer sciences
- engineering and technology chemical engineering separation technologies
- natural sciences chemical sciences catalysis
- natural sciences chemical sciences physical chemistry
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
VIENNA
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.