IL-7 dependent commitment of lymphoid progenitors to the B cell pathway

Project Information

STATPAX

Grant agreement ID: 11190

Project closed

Start date 1 March 2005

End date 28 February 2007

Funded under

• Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006

Total cost No data

EU contribution € 157 886,00

Coordinated by

RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY (IMP)
Austria

Objective

During the course of evolution, the immune system has developed to defend us against infections by creating a diverse number of specialized cell types. B-lymphocytes are produced by the differentiation of hematopoietic stem cells (HSC) into gradually more lineage-restricted progenitors. This B cell pathway requires the coordinate action of the early transcription factors PU.1 and Ikaros prior to the activation of the B-cell-specific regulators E2A, EBF and Pax5. In addition, interleukin-7 (IL-7) signalling instructs the initial differentiation of B-lymphocytes from the common lymphoid progenitor. This project will investigate how IL-7 signalling, through activation of the transcription factor STAT5, is integrated into the transcriptional control of early B c ell development.

Fields of science

• medical and health sciences › basic medicine › immunology
• medical and health sciences › medical biotechnology › cells technologies › stem cells
• natural sciences › biological sciences › genetics › mutation

Keywords

• Epigenetics
• Transcription
• lymphocyte

Programme(s)

• FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006

Topic(s)

• MOBILITY-2.1 - Marie Curie Intra-European Fellowships (EIF)

Call for proposal

FP6-2002-MOBILITY-5
See other projects for this call

Funding Scheme

EIF - Marie Curie actions-Intra-European Fellowships

Coordinator

RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY (IMP)

• EU contribution: No data
• Address: Dr. Bohr-Gasse 7 ; VIENNA ; Austria
• Total cost: No data