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IL-7 dependent commitment of lymphoid progenitors to the B cell pathway

Objectif

During the course of evolution, the immune system has developed to defend us against infections by creating a diverse number of specialized cell types. B-lymphocytes are produced by the differentiation of hematopoietic stem cells (HSC) into gradually more lineage-restricted progenitors. This B cell pathway requires the coordinate action of the early transcription factors PU.1 and Ikaros prior to the activation of the B-cell-specific regulators E2A, EBF and Pax5. In addition, interleukin-7 (IL-7) signalling instructs the initial differentiation of B-lymphocytes from the common lymphoid progenitor. This project will investigate how IL-7 signalling, through activation of the transcription factor STAT5, is integrated into the transcriptional control of early B c ell development.

Champ scientifique (EuroSciVoc)

Mots‑clés

Thème(s)

Appel à propositions

FP6-2002-MOBILITY-5
Voir d’autres projets de cet appel

Régime de financement

EIF - Marie Curie actions-Intra-European Fellowships

Coordinateur

RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY (IMP)
Contribution de l’UE
Aucune donnée
Coût total
Aucune donnée