Objectif During the course of evolution, the immune system has developed to defend us against infections by creating a diverse number of specialized cell types. B-lymphocytes are produced by the differentiation of hematopoietic stem cells (HSC) into gradually more lineage-restricted progenitors. This B cell pathway requires the coordinate action of the early transcription factors PU.1 and Ikaros prior to the activation of the B-cell-specific regulators E2A, EBF and Pax5. In addition, interleukin-7 (IL-7) signalling instructs the initial differentiation of B-lymphocytes from the common lymphoid progenitor. This project will investigate how IL-7 signalling, through activation of the transcription factor STAT5, is integrated into the transcriptional control of early B c ell development. Champ scientifique medical and health sciencesbasic medicineimmunologymedical and health sciencesmedical biotechnologycells technologiesstem cellsnatural sciencesbiological sciencesgeneticsmutation Mots‑clés Epigenetics Transcription lymphocyte Programme(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Thème(s) MOBILITY-2.1 - Marie Curie Intra-European Fellowships (EIF) Appel à propositions FP6-2002-MOBILITY-5 Voir d’autres projets de cet appel Régime de financement EIF - Marie Curie actions-Intra-European Fellowships Coordinateur RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY (IMP) Contribution de l’UE Aucune donnée Adresse Dr. Bohr-Gasse 7 VIENNA Autriche Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée
