Final Activity Report Summary - STATPAX (IL-7 dependent commitment of lymphoid progenitors to the B cell pathway)
B Lymphocytes produce antibodies which are important for humoral immunity. This project integrated the role of IL-7 signalling into our current understanding of the transcriptional control of B cell development. The experiments provided novel and important insights by determining the molecular consequences of IL-7 signalling for early B cell development. The interleukin7 receptor was composed in part by the common gamma chain receptor as well. A common cause of human x-linked severe combined immunodeficiency was caused by a mutation in this common gamma chain receptor. We thus added to our knowledge on how this signalling axis works.