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SUrrogate markers for vascular Micro- and Macrovascular hard endpoints for Innovative diabetes Tools

Objective

Diabetes mellitus is a lifelong, incapacitating disease affecting multiple organs. Worldwide prevalence figures estimate that there will be 246 million diabetic patients in 2007 and 380 million in 2025. Presently, diabetes can neither be prevented nor cured and the disease is associated with devastating chronic complications including coronary heart disease and stroke (macrovascular disease) as well as microvascular disorders leading to damage of the small blood vessels of the kidney (nephropathy), eye(retinopathy) and peripheral nerves (neuropathy). These complications impose an immense burden on the quality of life of the patients and account for more than 10% of health care costs in Europe. Therefore, novel means to prevent these devastating diabetic complications are needed. An important mean in this undertaking would be to develop tools which would make development of novel drugs for prevention of complications more feasible. The SUMMIT consortium brings together European key leaders in the field of diabetes research; scientists with a deep insight into genetics, biomarker discovery, development of novel imaging assays for assessing progression of complications, novel animal models for chronic diabetic complications, in silico models to predict development of complications and response to novel treatments. Given the track record of this unique group of scientists, it can be anticipated that they will not only during the 6-year period discover novel surrogate markers for vascular complications in diabetes, but also validate them in large representative cohorts aiming at prevention of the devastating complications.

Field of science

  • /medical and health sciences/basic medicine/neurology/stroke
  • /medical and health sciences/clinical medicine/ophthalmology/retinopathy
  • /natural sciences/biological sciences/genetics and heredity
  • /medical and health sciences/clinical medicine/endocrinology/diabetes

Call for proposal

IMI-JU-01-2008
See other projects for this call

Funding Scheme

JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI)

Coordinator

BOEHRINGER INGELHEIM INTERNATIONALGMBH
Address
Binger Strasse
55218 Ingelheim
Germany
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Principal investigator
Michael Mark (Dr.)
Administrative Contact
Megan Grether (Dr.)

Participants (25)

MAX IV Laboratory, Lund University
Sweden
EU contribution
€ 4 413 330
Address
Paradisgatan 5C
22100 Lund
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jacqueline Postma (Dr.)
BIOCOMPUTING PLATFORMS LTD OY
Finland
EU contribution
€ 181 873
Address
Innopoli 3 Vaisalantie 6
02130 Espoo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Anita Eliasson (Ms.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 959 999
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Caroline Hamilton (Ms.)
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
EU contribution
€ 592 320
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Activity type
Research Organisations
Administrative Contact
Juergen Ertel (Dr.)
ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Italy
EU contribution
€ 184 999
Address
Via Mario Negri 2
20156 Milano
Activity type
Research Organisations
Administrative Contact
Maria Grazia Pezzoni (Ms)
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 234 998
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Keith Cann (Mr)
UNIVERSITY OF DUNDEE
United Kingdom
EU contribution
€ 2 500 280
Address
Nethergate
DD1 4HN Dundee
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Diane Taylor (Ms)
THE UNIVERSITY OF EXETER
United Kingdom
EU contribution
€ 465 999
Address
The Queen's Drive Northcote House
EX4 4QJ Exeter
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Catherine Serjeant (-)
GOETEBORGS UNIVERSITET
Sweden
EU contribution
€ 162 618
Address
Vasaparken
405 30 Goeteborg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tinna Carlsson (-)
SAMFUNDET FOLKHALSAN I SVENSKA FINLAND RF
Finland
EU contribution
€ 450 258
Address
Topeliusgatan 20
00250 Helsinki
Activity type
Research Organisations
Administrative Contact
Christer Holmström (Mr.)
TERVEYDEN JA HYVINVOINNIN LAITOS
Finland
EU contribution
€ 228 946
Address
Mannerheimintie 166
00271 Helsinki
Activity type
Research Organisations
Administrative Contact
Janne Luomala (Mr.)
ITA-SUOMEN YLIOPISTO
Finland
EU contribution
€ 1 246 775
Address
Yliopistonranta 1 E
70211 Kuopio
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Seppo Ylä-Herttuala (Prof)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 701 629
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Edward Gibbs (Mr)
UNIVERSITA DEGLI STUDI DI PADOVA
Italy
EU contribution
€ 432 259
Address
Via 8 Febbraio 2
35122 Padova
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Antonio Camporese (Dott.)
UNIVERSITA DEGLI STUDI DI PAVIA
Italy
EU contribution
€ 292 499
Address
Strada Nuova 65
27100 Pavia
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sofia Baggini (Dr.)
UNIVERSITA DI PISA
Italy
EU contribution
€ 455 404
Address
Lungarno Pacinotti 43/44
56126 Pisa
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Perini Elena (Dr.)
UNIVERSITA CATTOLICA DEL SACRO CUORE
Italy
EU contribution
€ 319 999
Address
Largo Gemelli 1
20123 Milano
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Filippo Leone (Mr.)
TURUN YLIOPISTO
Finland
EU contribution
€ 370 625
Address
Yliopistonmaki
20014 Turku
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eliisa Särkilahti (Dr.)
THE UNIVERSITY OF EDINBURGH
United Kingdom
EU contribution
€ 309 749
Address
Old College, South Bridge
EH8 9YL Edinburgh
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Angela Noble (Ms)
Eli Lilly and Company Limited
United Kingdom
Address
Lilly House, Priestley Road
RG24 9NL Basingstoke
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Birgit Steckel-Hamann (Dr.)
ASTRAZENECA AB
Sweden
Address
Vastra Maelarhamnen
151 85 Sodertaelje
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Eva Lindgren (Senior Director)
F. HOFFMANN-LA ROCHE AG
Switzerland
Address
Grenzacherstrasse 124
4070 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jason Hannon (Dr)
UNIVERSITA DEGLI STUDI DI FIRENZE
Italy
EU contribution
€ 150 000
Address
Piazza San Marco 4
50121 Florence
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Cristina Dolfi (-)
SANOFI-AVENTIS DEUTSCHLAND GMBH
Germany
Address
Bruningstrasse 50
65929 Frankfurt Am Main
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Bernd Jablonka (Dr)
PFIZER LIMITED
United Kingdom
Address
Ramsgate Road
CT13 9NJ Sandwich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Olga Krylova (Dr.)