Cel
Rationale
The inability of pre-clinical studies to predict clinical efficacy is a major bottleneck in drug development. In severe asthma this bottleneck results from: a lack of useful and validated biomarkers, underperforming pre-clinical models, inadequate and incomplete sub-phenotyping, and insufficient disease understanding.
Hypothesis
The use of biomarker profiles comprised of various types of high-dimensional data, integrated with an innovative systems biology approach into distinct phenotype handprints, will enable significantly better prediction of therapeutic efficacy than single or even clustered biomarkers of one data type and will identify novel targets.
Strategy
U-BIOPRED proposes a staged-strategy:
I)Generating an international consensus on diagnostic criteria for severe asthma.
II)Unbiased discovery of sub-phenotypes of severe asthma in adult and paediatric patient cohorts using biomarker profiles (“fingerprints”) and systems biology to define “phenotype/handprints”.
III)Validating the handprints for exacerbations, disease progression, and experimental challenges.
IV)Using the handprints to improve human/animal in vivo and ex vivo models.
V)Establishing the responsiveness and predictability of the handprints in gold standard and experimental therapeutic interventions.
VI)Refinement of the diagnostic criteria and definition of severe asthma sub-phenotypes by incorporating the handprints, thereby enabling more focused drug development and faster delivery proof of concept for novel drugs.
VII)Education, training and dissemination through a stakeholder platform and academic-industrial exchange, with potential for further growth as appropriate.
Innovative approach
We will use a novel systems biology approach to integrate high dimensional data from invasive, non-invasive and patient-reported outcomes. All studies will include academic and EFPIA partners as active contributors.
Dziedzina nauki
Zaproszenie do składania wniosków
IMI-JU-01-2008
Zobacz inne projekty w ramach tego zaproszenia
System finansowania
JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI)Koordynator
4056 Basel
Szwajcaria
Zobacz na mapie
Uczestnicy (41)
1105AZ Amsterdam
Zobacz na mapie
SO17 1BJ Southampton
Zobacz na mapie
SW7 2AZ LONDON
Zobacz na mapie
95131 Catania
Zobacz na mapie
00133 Roma
Zobacz na mapie
2650 Hvidovre
Zobacz na mapie
31-007 Krakow
Zobacz na mapie
3012 Bern
Zobacz na mapie
1085 Budapest
Zobacz na mapie
M13 9PL Manchester
Zobacz na mapie
13284 Marseille
Zobacz na mapie
80686 Munchen
Zobacz na mapie
901 87 Umea
Zobacz na mapie
9000 Gent
Zobacz na mapie
75794 Paris
Zobacz na mapie
20123 Milano
Zobacz na mapie
1165 Kobenhavn
Zobacz na mapie
17177 Stockholm
Zobacz na mapie
NG7 2RD Nottingham
Zobacz na mapie
5020 Bergen
Zobacz na mapie
3831PE Leusden
Zobacz na mapie
S10 2PX Sheffield
Zobacz na mapie
E1 8AA LONDON
Zobacz na mapie
1000 BRUXELLES
Zobacz na mapie
95127 Catania
Zobacz na mapie
EH2 4JN Edinburgh
Zobacz na mapie
5656 AG Eindhoven
Zobacz na mapie
S0166YD SOUTHAMPTON
Zobacz na mapie
75450 UPPSALA
Zobacz na mapie
3631 Maasmechelen
Zobacz na mapie
08022 Barcelona
Zobacz na mapie
151 85 Sodertaelje
Zobacz na mapie
55218 Ingelheim
Zobacz na mapie
43122 Parma
Zobacz na mapie
TW89GS Brentford
Zobacz na mapie
Zakończenie uczestnictwa
CT13 9NJ Sandwich
Zobacz na mapie
4070 Basel
Zobacz na mapie
1070 Bruxelles / Brussel
Zobacz na mapie
2300AG Leiden
Zobacz na mapie
1831 Diegem
Zobacz na mapie
08889 Whitehouse Station Nj
Zobacz na mapie