Objectif
Model based-drug development (MBDD) is accepted as a vital approach in understanding patient risk/benefit and attrition. At the core of MBDD lies Modelling and Simulation (M&S), a technology providing the basis for informed, quantitative decision-making.
M&S facilitates the continuous integration of available information related to a drug or disease into constantly-evolving mathematical models capable of describing and predicting the behaviour of studied systems to address the questions researchers, regulators, and public health care bodies face when bringing drugs to patients.
The full adoption of MBDD is frustrated by a lack of common tools, languages and ontologies for M&S, which often leads to inefficient reuse of data and duplication of effort by academic, industrial and regulatory stakeholders.
The Drug Disease Model Resources (DDMoRe) consortium’s strategy will have standards as its core: a newly developed common definition language for data, models and workflows, along with an ontology based standard for storage and transfer of models and associated metadata.
A drug and disease model library will be developed as a public resource. Its flexibility and power will be showcased by the addition of “proof of concept” drug and disease models from key therapeutic areas such as diabetes and oncology.
An open-source interoperability framework will be the backbone for the integration of M&S applications into seamless, standardized but flexible workflows. Initially, currently-used tools (e.g. NONMEM, WinBUGS, Matlab, R) will be integrated into the framework. From the outset resources will also be dedicated to new application development which will be steered by identified gaps in the M&S software ecosystem.
The DDMoRe project’s standards and tools – intended as the gold standard for future collaborative drug and disease M&S - will be supported by comprehensive training and will be made publicly accessible.
Champ scientifique
- natural sciencescomputer and information sciencesknowledge engineeringontology
- natural sciencescomputer and information sciencessoftware
- medical and health scienceshealth sciencespublic health
- natural sciencesbiological sciencesecologyecosystems
- natural sciencesmathematicsapplied mathematicsmathematical model
Appel à propositions
IMI-JU-02-2009
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Régime de financement
JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI)Coordinateur
CT13 9NJ Sandwich
Royaume-Uni
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Participants (27)
751 05 Uppsala
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69117 Heidelberg
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SG1 2EF Stevenage
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2311 EZ Leiden
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27100 Pavia
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78153 Le Chesnay Cedex
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EC2Y 5EB London
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OX14 4RZ Abingdon Oxfordshire
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00185 Roma
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6108 Halle
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F-75205 / 13 Paris
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31080 Pamplona
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6299920 Tel Aviv
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4056 Basel
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151 85 Sodertaelje
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TW89GS Brentford
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RG21 4FA Basingstoke
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64293 Darmstadt
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2880 Bagsvaerd
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4070 Basel
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92284 Courbevoie
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1070 Bruxelles / Brussel
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1000 Bruxelles
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14195 Berlin
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92160 Antony
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WC1E 6BT London
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8152 Glattpark
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