Objetivo
Model based-drug development (MBDD) is accepted as a vital approach in understanding patient risk/benefit and attrition. At the core of MBDD lies Modelling and Simulation (M&S), a technology providing the basis for informed, quantitative decision-making.
M&S facilitates the continuous integration of available information related to a drug or disease into constantly-evolving mathematical models capable of describing and predicting the behaviour of studied systems to address the questions researchers, regulators, and public health care bodies face when bringing drugs to patients.
The full adoption of MBDD is frustrated by a lack of common tools, languages and ontologies for M&S, which often leads to inefficient reuse of data and duplication of effort by academic, industrial and regulatory stakeholders.
The Drug Disease Model Resources (DDMoRe) consortium’s strategy will have standards as its core: a newly developed common definition language for data, models and workflows, along with an ontology based standard for storage and transfer of models and associated metadata.
A drug and disease model library will be developed as a public resource. Its flexibility and power will be showcased by the addition of “proof of concept” drug and disease models from key therapeutic areas such as diabetes and oncology.
An open-source interoperability framework will be the backbone for the integration of M&S applications into seamless, standardized but flexible workflows. Initially, currently-used tools (e.g. NONMEM, WinBUGS, Matlab, R) will be integrated into the framework. From the outset resources will also be dedicated to new application development which will be steered by identified gaps in the M&S software ecosystem.
The DDMoRe project’s standards and tools – intended as the gold standard for future collaborative drug and disease M&S - will be supported by comprehensive training and will be made publicly accessible.
Ámbito científico
- natural sciencescomputer and information sciencesknowledge engineeringontology
- natural sciencescomputer and information sciencessoftware
- medical and health scienceshealth sciencespublic health
- natural sciencesbiological sciencesecologyecosystems
- natural sciencesmathematicsapplied mathematicsmathematical model
Convocatoria de propuestas
IMI-JU-02-2009
Consulte otros proyectos de esta convocatoria
Régimen de financiación
JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI)Coordinador
CT13 9NJ Sandwich
Reino Unido
Ver en el mapa
Participantes (27)
751 05 Uppsala
Ver en el mapa
69117 Heidelberg
Ver en el mapa
SG1 2EF Stevenage
Ver en el mapa
2311 EZ Leiden
Ver en el mapa
27100 Pavia
Ver en el mapa
78153 Le Chesnay Cedex
Ver en el mapa
EC2Y 5EB London
Ver en el mapa
OX14 4RZ Abingdon Oxfordshire
Ver en el mapa
00185 Roma
Ver en el mapa
La participación finalizó
6108 Halle
Ver en el mapa
F-75205 / 13 Paris
Ver en el mapa
31080 Pamplona
Ver en el mapa
6299920 Tel Aviv
Ver en el mapa
4056 Basel
Ver en el mapa
151 85 Sodertaelje
Ver en el mapa
TW89GS Brentford
Ver en el mapa
RG21 4FA Basingstoke
Ver en el mapa
64293 Darmstadt
Ver en el mapa
2880 Bagsvaerd
Ver en el mapa
4070 Basel
Ver en el mapa
92284 Courbevoie
Ver en el mapa
1070 Bruxelles / Brussel
Ver en el mapa
La participación finalizó
1000 Bruxelles
Ver en el mapa
14195 Berlin
Ver en el mapa
92160 Antony
Ver en el mapa
WC1E 6BT London
Ver en el mapa
8152 Glattpark
Ver en el mapa