Objective
The ABIRISK project provides an integrated approach to the study of immunization against biopharmaceuticals, bringing together a unique panel of experts from different disciplines.
ABIRISK will involve many of the European leaders in rheumatology, gastroenterology, hemophilia and multiple sclerosis, caring for ~30,000 patients treated with biopharmaceuticals, with ~10,000 additional patients recruited per year. This should lead to the constitution of the largest possible cohort in Europe for the study of immunogenicity, a condition critical for the success of the program. ABIRISK will also benefit from the unique expertise of immunologist partners in the development of innovative strategies for predicting the immunogenicity of biopharmaceuticals and for defining its mechanisms. The large number of patients enrolled in the ABIRISK cohorts should make it possible to study the genetic basis of immunogenicity in a new way.
We will standardize all clinical and biological information before its integration into a large database for evaluation of the clinical relevance of immunization against biopharmaceuticals and stratification of the risk to patients as a function of factors linked to treatment or to the individual. Computational biology and biostatistical modeling will be used to develop models for predicting immunogenicity that will be validated with the ABIRISK database.
The complementarity between the clinical partners from different disciplines, immunologists, methodologists and biostatisticians will create a unique task force for studies of biopharmaceutical immunogenicity. The direct outcomes of the proposed work will be greater understanding of the mechanisms involved in the emergence of anti-drug antibodies, the development of new methods for predicting immunogenicity and a comprehensive view of the respective value of predictive tools, and guidelines for the development of new biopharmaceuticals and patient care.
Fields of science
- medical and health sciencesclinical medicinerheumatology
- natural sciencescomputer and information sciencesdatabases
- medical and health sciencesbasic medicineimmunologyimmunisation
- medical and health sciencesbasic medicineneurologymultiple sclerosis
- medical and health sciencesclinical medicinegastroenterology
Call for proposal
IMI-JU-03-2010
See other projects for this call
Coordinator
NOVARTIS PHARMA AG
EU contribution
No data
Address
LICHTSTRASSE 35
4056 Basel
Switzerland
4056 Basel
Switzerland
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Region
Schweiz/Suisse/Svizzera
Nordwestschweiz
Basel-Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Principal investigator
Sebastian Spindeldreher (Dr.)
Administrative Contact
Barbara Stolz (Dr.)
Links
Total cost
No data
Participants (37)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 3 807 426,00
Address
RUE DE TOLBIAC 101
75654 Paris
75654 Paris
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Region
Ile-de-France
Ile-de-France
Paris
Activity type
Research Organisations
Administrative Contact
Laurence PARMANTIER (Ms.)
Links
Total cost
No data
UNIVERSITA DEGLI STUDI DI FIRENZE
Italy
EU contribution
€ 610 139,00
Address
Piazza San Marco 4
50121 Florence
50121 Florence
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Region
Centro (IT)
Toscana
Firenze
Activity type
Higher or Secondary Education Establishments
Administrative Contact
CRISTINA DOLFI (Dr.)
Links
Total cost
No data
FONDAZIONE PER L'ISTITUTO DI RICERCA IN BIOMEDICINA
Switzerland
EU contribution
€ 729 599,00
Address
VIA FRANCESCO CHIESA 5
6500 Bellinzona
6500 Bellinzona
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Region
Schweiz/Suisse/Svizzera
Ticino
Ticino
Activity type
Research Organisations
Administrative Contact
Giorgio Noseda (Prof.)
Links
Total cost
No data
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU contribution
€ 739 970,00
Address
RUE LEBLANC 25
75015 PARIS 15
75015 PARIS 15
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Region
Ile-de-France
Ile-de-France
Paris
Activity type
Research Organisations
Administrative Contact
ELIANE DECK-CHAUMONT (Ms.)
Links
Total cost
No data
Biomonitor A/S
Denmark
EU contribution
€ 627 000,00
Address
Fruebjergvej
DK-2100 Copenhagen
DK-2100 Copenhagen
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Administrative Contact
Marie Holde-Jensen (Ms.)
Links
Total cost
No data
UNIVERSITY COLLEGE LONDON
United Kingdom
EU contribution
€ 1 683 976,00
Address
GOWER STREET
WC1E 6BT London
WC1E 6BT London
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Region
London
Inner London — West
Camden and City of London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Greta Borg-Carbott (Ms.)
Links
Total cost
No data
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 555 396,00
Address
ALBINUSDREEF 2
2333 ZA Leiden
2333 ZA Leiden
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Region
West-Nederland
Zuid-Holland
Agglomeratie Leiden en Bollenstreek
Activity type
Higher or Secondary Education Establishments
Administrative Contact
J. J. (John) Van Roozendaal (Dr)
Links
Total cost
No data
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 799 973,00
Address
MEIBERGDREEF 15
1105AZ Amsterdam
1105AZ Amsterdam
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Region
West-Nederland
Noord-Holland
Groot-Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Erwin J. Van der Meijden (Dr)
Links
Total cost
No data
ISTITUTO GIANNINA GASLINI
Italy
EU contribution
€ 422 175,00
Address
VIA GEROLAMO GASLINI 5
16147 Genova
16147 Genova
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Region
Nord-Ovest
Liguria
Genova
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Gabriella Marinari (Dr.)
Links
Total cost
No data
GROUPE D'ETUDES THERAPEUTIQUES DES AFFECTIONS INFLAMMATOIRES DIGESTIVES ASSOCIATION
France
EU contribution
€ 494 079,00
Address
2 RUE AMBROISE PARE
75010 Paris
75010 Paris
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Region
Ile-de-France
Ile-de-France
Paris
Activity type
Research Organisations
Administrative Contact
JULIE DEMOLIN (Mme.)
Links
Total cost
No data
THE HEALTH CORPORATION - RAMBAM
Israel
EU contribution
€ 151 883,00
Address
HAALIYA 8
31096 Haifa
31096 Haifa
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Activity type
Research Organisations
Administrative Contact
Ronya Rubinstein (Dr.)
Links
Total cost
No data
UNIVERSITATSKLINIKUM BONN
Germany
EU contribution
€ 536 309,00
Address
VENUSBERG-CAMPUS 1
53127 Bonn
53127 Bonn
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Region
Nordrhein-Westfalen
Köln
Bonn, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Beate Becker (Ms.)
Links
Total cost
No data
BUNDESINSTITUT FUR IMPFSTOFFE UND BIOMEDIZINISCHE ARZNEIMITTEL
Germany
EU contribution
€ 633 868,00
Address
PAUL-EHRLICH-STRASSE 51-59
63225 Langen
63225 Langen
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Region
Hessen
Darmstadt
Offenbach, Landkreis
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Stefanie Larisch (Ms.)
Links
Total cost
No data
JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
Germany
EU contribution
€ 526 630,00
Address
THEODOR W ADORNO PLATZ 1
60323 Frankfurt Am Main
60323 Frankfurt Am Main
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Region
Nordrhein-Westfalen
Arnsberg
Siegen-Wittgenstein
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christoph Königs (Dr.)
Links
Total cost
No data
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 570 619,00
Address
Nobels Vag 5
17177 Stockholm
17177 Stockholm
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Region
Östra Sverige
Stockholm
Stockholms län
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Johan Forsslöf (Dr.)
Links
Total cost
No data
MEDIZINISCHE UNIVERSITAT INNSBRUCK
Austria
EU contribution
€ 714 470,00
Address
CHRISTOPH PROBST PLATZ 1
6020 Innsbruck
6020 Innsbruck
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Region
Westösterreich
Tirol
Innsbruck
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Florian Deisenhammer (Prof.)
Links
Total cost
No data
HEINRICH-HEINE-UNIVERSITAET DUESSELDORF
Germany
EU contribution
€ 536 525,00
Address
UNIVERSITAETSSTRASSE 1
40225 Dusseldorf
40225 Dusseldorf
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Region
Nordrhein-Westfalen
Düsseldorf
Düsseldorf, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thomas Dehmel (Dr.)
Links
Total cost
No data
REGION HOVEDSTADEN
Denmark
EU contribution
€ 306 812,00
Address
KONGENS VAENGE 2
3400 Hillerod
3400 Hillerod
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Region
Danmark
Hovedstaden
Nordsjælland
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Per Soelberg Sorensen (PROF.)
Links
Total cost
No data
UNIVERSITATSSPITAL BASEL
Switzerland
EU contribution
€ 229 481,00
Address
HEBELSTRASSE 32
4031 Basel
4031 Basel
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Region
Schweiz/Suisse/Svizzera
Nordwestschweiz
Basel-Stadt
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Ludwig Kappos (MD)
Links
Total cost
No data
FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA
Spain
EU contribution
€ 353 678,00
Address
PASSEIG VALL D HEBRON 119-129 EDIFICIO DE RECERCA
08035 Barcelona
08035 Barcelona
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Region
Este
Cataluña
Barcelona
Activity type
Research Organisations
Administrative Contact
Lluis Masso (Mr.)
Links
Total cost
No data
QUEEN MARY UNIVERSITY OF LONDON
United Kingdom
EU contribution
€ 261 905,00
Address
327 MILE END ROAD
E1 4NS London
E1 4NS London
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Region
London
Inner London — West
Camden and City of London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
TANYA SZENDEFFY (Ms.)
Links
Total cost
No data
KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN
Germany
EU contribution
€ 658 000,00
Address
ISMANINGER STRASSE 22
81675 Muenchen
81675 Muenchen
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Region
Bayern
Oberbayern
München, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Renate Rädlein (Dr.)
Links
Total cost
No data
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 411 157,00
Address
RUE MICHEL ANGE 3
75794 Paris
75794 Paris
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Region
Ile-de-France
Ile-de-France
Paris
Activity type
Research Organisations
Administrative Contact
Camille SEZE-GOIMIER (Ms)
Links
Total cost
No data
ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU
Italy
EU contribution
€ 438 672,00
Address
VIA FIORENTINA 151
53100 Siena
53100 Siena
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Region
Centro (IT)
Toscana
Siena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Natascia Cannella (Dr.)
Links
Total cost
No data
DRK-BLUTSPENDEDIENST BADEN-WURTTEMBERG-HESSEN GGMBH
Germany
EU contribution
€ 268 372,00
Address
FRIEDRICH EBERT STRASSE 107
68167 Mannheim
68167 Mannheim
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Region
Baden-Württemberg
Karlsruhe
Mannheim, Stadtkreis
Activity type
Research Organisations
Administrative Contact
Jörg Schüttrumpf (Dr.med.)
Links
Total cost
No data
UNIVERZITA KARLOVA
Czechia
EU contribution
€ 307 839,00
Address
OVOCNY TRH 560/5
116 36 Praha 1
116 36 Praha 1
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Region
Česko
Praha
Hlavní město Praha
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kristyna Matejkova (Dr.)
Links
Total cost
No data
PFIZER LIMITED
United Kingdom
EU contribution
No data
Address
RAMSGATE ROAD
CT13 9NJ Sandwich
CT13 9NJ Sandwich
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Region
South East (England)
Kent
East Kent
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Olga Krylova (Dr)
Links
Total cost
No data
GLAXOSMITHKLINE RESEARCH & DEVELOPMENT LIMITED
United Kingdom
EU contribution
No data
Address
79 NEW OXFORD STREET,
WC1A 1DG LONDON
WC1A 1DG LONDON
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Region
London
Inner London — West
Camden and City of London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Sally Miles (-)
Links
Total cost
No data
UCB PHARMA SA
Belgium
EU contribution
No data
Address
ALLEE DE LA RECHERCHE 60
1070 Bruxelles / Brussel
1070 Bruxelles / Brussel
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Region
Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest
Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest
Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Simon Dresse (Mr.)
Links
Total cost
No data
SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT
France
EU contribution
No data
Address
82 AVENUE RASPAIL
94250 GENTILLY
94250 GENTILLY
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Region
Ile-de-France
Ile-de-France
Val-de-Marne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Nathalie PITON (Dr.)
Links
Total cost
No data
MERCK KOMMANDITGESELLSCHAFT AUF AKTIEN
Germany
EU contribution
No data
Address
FRANKFURTER STRASSE 250
64293 Darmstadt
64293 Darmstadt
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Region
Hessen
Darmstadt
Darmstadt, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ninog Péresse (Mrs.)
Links
Total cost
No data
NOVO NORDISK A/S
Denmark
EU contribution
No data
Address
NOVO ALLE 1
2880 Bagsvaerd
2880 Bagsvaerd
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Region
Danmark
Hovedstaden
Københavns omegn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jørgen Dirach (Dr.)
Links
Total cost
No data
Bayer Pharma AG
Germany
EU contribution
No data
Address
Muellerstrasse 178
13353 Berlin
13353 Berlin
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Region
Berlin
Berlin
Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Petra Freitag (Ms)
Links
Total cost
No data
IPSEN INNOVATION SAS
France
EU contribution
No data
Address
AVENUE DU CANADA - ZONE INDUSTRIELLE DE COURTABOEUF 5
91940 Les Ulis
91940 Les Ulis
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Region
Ile-de-France
Ile-de-France
Essonne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Philippe Bardin (Mr.)
Links
Total cost
No data
MEDICAL RESEARCH INFRASTRUCTURE DEVELOPMENT AND HEALTH SERVICES FUND BY THE SHEBA MEDICAL CENTER
Israel
EU contribution
€ 12 680,00
Address
TEL HASHOMER SHEBA MEDICAL CENTER
52621 Ramat Gan
52621 Ramat Gan
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Activity type
Research Organisations
Administrative Contact
Eve Keret (Ms)
Links
Total cost
No data
SciCross AB
Sweden
EU contribution
€ 345 958,00
Address
GOTHIA SCIENCE PARK
54123 SKOVDE
54123 SKOVDE
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Administrative Contact
Pierre Dönnes (PhD)
Links
Total cost
No data
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
EU contribution
€ 435 626,00
Address
55 BOULEVARD DIDEROT
75012 Paris
75012 Paris
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Region
Ile-de-France
Ile-de-France
Val-de-Marne
Activity type
Research Organisations
Administrative Contact
Alix PILLOT (Mrs)
Links
Total cost
No data